FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034501941> ?p ?o ?g. }

• W2034501941 endingPage "e56901" @default.
• W2034501941 startingPage "e56901" @default.
• W2034501941 abstract "Neural progenitors in the developing neocortex, neuroepithelial cells and radial glial cells, have a bipolar shape with a basal process contacting the basal membrane of the meninge and an apical plasma membrane facing the lateral ventricle, which the cerebrospinal fluid is filled with. Recent studies revealed that the meninges and the cerebrospinal fluid have certain roles to regulate brain development. γ-aminobutyric acid (GABA) is a neurotransmitter which appears first during development and works as a diffusible factor to regulate the properties of neural progenitors. In this study, we examined whether GABA can be released from the meninges and the choroid plexus in the developing mouse brain. Immunohistochemical analyses showed that glutamic acid decarboxylase 65 and 67 (GAD65 and GAD67), both of which are GABA-synthesizing enzymes, are expressed in the meninges. The epithelial cells in the choroid plexus express GAD65. GABA immunoreactivity could be observed beneath the basal membrane of the meninge and in the epithelial cells of the choroid plexus. Expression analyses on Bestrophin-1, which is known as a GABA-permeable channel in differentiated glial cells, suggested that the cells in the meninges and the epithelial cells in the choroid plexus have the channels able to permeate non-synaptic GABA into the extracellular space. Further studies showed that GAD65/67-expressing meningeal cells appear in a manner with rostral to caudal and lateral to dorsal gradient to cover the entire neocortex by E14.5 during development, while the cells in the choroid plexus in the lateral ventricle start to express GAD65 on E11–E12, the time when the choroid plexus starts to develop in the developing brain. These results totally suggest that the meninges and the choroid plexus can work as non-neuronal sources for ambient GABA which can modulate the properties of neural progenitors during neocortical development." @default.
• W2034501941 created "2016-06-24" @default.
• W2034501941 creator A5024515865 @default.
• W2034501941 creator A5061580903 @default.
• W2034501941 date "2013-02-20" @default.
• W2034501941 modified "2023-09-25" @default.
• W2034501941 title "Immunoreactivity for GABA, GAD65, GAD67 and Bestrophin-1 in the Meninges and the Choroid Plexus: Implications for Non-Neuronal Sources for GABA in the Developing Mouse Brain" @default.
• W2034501941 cites W1705218924 @default.
• W2034501941 cites W1967611229 @default.
• W2034501941 cites W1994532676 @default.
• W2034501941 cites W1996090995 @default.
• W2034501941 cites W2007034511 @default.
• W2034501941 cites W2009567472 @default.
• W2034501941 cites W2016540367 @default.
• W2034501941 cites W2019220811 @default.
• W2034501941 cites W2025029334 @default.
• W2034501941 cites W2030683717 @default.
• W2034501941 cites W2045358831 @default.
• W2034501941 cites W2054608145 @default.
• W2034501941 cites W2059216629 @default.
• W2034501941 cites W2065031748 @default.
• W2034501941 cites W2066011849 @default.
• W2034501941 cites W2078981560 @default.
• W2034501941 cites W2083058184 @default.
• W2034501941 cites W2083131697 @default.
• W2034501941 cites W2095802030 @default.
• W2034501941 cites W2098927213 @default.
• W2034501941 cites W2136019653 @default.
• W2034501941 cites W2139998756 @default.
• W2034501941 cites W2147061036 @default.
• W2034501941 cites W2160205444 @default.
• W2034501941 cites W2160585801 @default.
• W2034501941 doi "https://doi.org/10.1371/journal.pone.0056901" @default.
• W2034501941 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3577695" @default.
• W2034501941 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23437266" @default.
• W2034501941 hasPublicationYear "2013" @default.
• W2034501941 type Work @default.
• W2034501941 sameAs 2034501941 @default.
• W2034501941 citedByCount "17" @default.
• W2034501941 countsByYear W20345019412014 @default.
• W2034501941 countsByYear W20345019412015 @default.
• W2034501941 countsByYear W20345019412016 @default.
• W2034501941 countsByYear W20345019412017 @default.
• W2034501941 countsByYear W20345019412018 @default.
• W2034501941 countsByYear W20345019412020 @default.
• W2034501941 countsByYear W20345019412021 @default.
• W2034501941 countsByYear W20345019412022 @default.
• W2034501941 countsByYear W20345019412023 @default.
• W2034501941 crossrefType "journal-article" @default.
• W2034501941 hasAuthorship W2034501941A5024515865 @default.
• W2034501941 hasAuthorship W2034501941A5061580903 @default.
• W2034501941 hasBestOaLocation W20345019411 @default.
• W2034501941 hasConcept C105702510 @default.
• W2034501941 hasConcept C136834591 @default.
• W2034501941 hasConcept C142724271 @default.
• W2034501941 hasConcept C169760540 @default.
• W2034501941 hasConcept C17077164 @default.
• W2034501941 hasConcept C181199279 @default.
• W2034501941 hasConcept C200707615 @default.
• W2034501941 hasConcept C2776403516 @default.
• W2034501941 hasConcept C2776538271 @default.
• W2034501941 hasConcept C2777222312 @default.
• W2034501941 hasConcept C2779177108 @default.
• W2034501941 hasConcept C2779651940 @default.
• W2034501941 hasConcept C28328180 @default.
• W2034501941 hasConcept C2909073510 @default.
• W2034501941 hasConcept C529278444 @default.
• W2034501941 hasConcept C55493867 @default.
• W2034501941 hasConcept C71924100 @default.
• W2034501941 hasConcept C86803240 @default.
• W2034501941 hasConcept C9497952 @default.
• W2034501941 hasConcept C95444343 @default.
• W2034501941 hasConceptScore W2034501941C105702510 @default.
• W2034501941 hasConceptScore W2034501941C136834591 @default.
• W2034501941 hasConceptScore W2034501941C142724271 @default.
• W2034501941 hasConceptScore W2034501941C169760540 @default.
• W2034501941 hasConceptScore W2034501941C17077164 @default.
• W2034501941 hasConceptScore W2034501941C181199279 @default.
• W2034501941 hasConceptScore W2034501941C200707615 @default.
• W2034501941 hasConceptScore W2034501941C2776403516 @default.
• W2034501941 hasConceptScore W2034501941C2776538271 @default.
• W2034501941 hasConceptScore W2034501941C2777222312 @default.
• W2034501941 hasConceptScore W2034501941C2779177108 @default.
• W2034501941 hasConceptScore W2034501941C2779651940 @default.
• W2034501941 hasConceptScore W2034501941C28328180 @default.
• W2034501941 hasConceptScore W2034501941C2909073510 @default.
• W2034501941 hasConceptScore W2034501941C529278444 @default.
• W2034501941 hasConceptScore W2034501941C55493867 @default.
• W2034501941 hasConceptScore W2034501941C71924100 @default.
• W2034501941 hasConceptScore W2034501941C86803240 @default.
• W2034501941 hasConceptScore W2034501941C9497952 @default.
• W2034501941 hasConceptScore W2034501941C95444343 @default.
• W2034501941 hasIssue "2" @default.
• W2034501941 hasLocation W20345019411 @default.
• W2034501941 hasLocation W20345019412 @default.
• W2034501941 hasLocation W20345019413 @default.
• W2034501941 hasLocation W20345019414 @default.
• W2034501941 hasOpenAccess W2034501941 @default.

• next