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- W2034502508 endingPage "302" @default.
- W2034502508 startingPage "289" @default.
- W2034502508 abstract "The identification of certain members of the large superfamily of ATP binding cassette transport proteins such as MDR1 -P-glycoprotein and the multidrug resistance protein MRP1 as ATP-dependent drug efflux pumps has been a major contribution in our understanding of the multidrug resistance phenotype of cancer cells. Importantly, both transport proteins that exhibit only low structural homology have a very different substrate specificity but confer resistance to a similar spectrum of natural product chemotherapeutic drugs. In contrast to the drug transporter MDR1, MRP1 mainly transports anionic Phase II-conjugates. In addition MRP1-mediated drug resistance is highly dependent on high intracellular glutathione levels which may be linked to the apparent physiological involvement of MRP1 in glutathione-related cellular processes. This review summarizes the current knowledge about functional aspects of MRP1 and its five recently cloned homologues MRP2–MRP6 and discusses their substrate specificities and cellular localization with emphasis on drug resistance." @default.
- W2034502508 created "2016-06-24" @default.
- W2034502508 creator A5001230537 @default.
- W2034502508 creator A5044769257 @default.
- W2034502508 creator A5058635640 @default.
- W2034502508 creator A5061495577 @default.
- W2034502508 date "2000-10-01" @default.
- W2034502508 modified "2023-09-25" @default.
- W2034502508 title "The (patho)physiological functions of the MRP family" @default.
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