Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034502720> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W2034502720 endingPage "394" @default.
- W2034502720 startingPage "386" @default.
- W2034502720 abstract "The response of plasma renin activity (PRA) to the stimuli of upright posture and sodium deprivation was determined in three normal adults and in ten hypertensive patients before and after chronic alpha-adrenergic receptor blockade with phenoxybenzamine and chronic beta-blockade with propranolol. Alpha-receptor blockade produced little effect on supine or upright PRA values; beta-receptor blockade, however, consistently and significantly suppressed PRA in both the supine and standing positions. Dose-response studies suggest that the maximal suppression of PRA attainable after oral propranolol administration occurs at peak plasma levels of about 30–50 ng/ml. Beta-adrenergic receptors appear to constitute that part of the sympathetic nervous system which mediates a significant portion of the renin release mechanism. Pharmacologic interference with renin secretion by beta-adrenergic receptor blockade is easily achieved in both normal and hypertensive subjects. The suppression of supine and upright PRA with beta-adrenergic blockade was not accompanied by decrease in blood pressure suggesting that, in addition to renin, other factors are involved in the pathogenesis of renal hypertension." @default.
- W2034502720 created "2016-06-24" @default.
- W2034502720 creator A5040583416 @default.
- W2034502720 creator A5042744295 @default.
- W2034502720 date "1972-02-01" @default.
- W2034502720 modified "2023-10-16" @default.
- W2034502720 title "The Effect of Chronic Adrenergic Receptor Blockade on Plasma Renin Activity in Man" @default.
- W2034502720 doi "https://doi.org/10.1210/jcem-34-2-386" @default.
- W2034502720 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4400632" @default.
- W2034502720 hasPublicationYear "1972" @default.
- W2034502720 type Work @default.
- W2034502720 sameAs 2034502720 @default.
- W2034502720 citedByCount "222" @default.
- W2034502720 countsByYear W20345027202012 @default.
- W2034502720 countsByYear W20345027202013 @default.
- W2034502720 crossrefType "journal-article" @default.
- W2034502720 hasAuthorship W2034502720A5040583416 @default.
- W2034502720 hasAuthorship W2034502720A5042744295 @default.
- W2034502720 hasConcept C125567185 @default.
- W2034502720 hasConcept C126322002 @default.
- W2034502720 hasConcept C134018914 @default.
- W2034502720 hasConcept C138976137 @default.
- W2034502720 hasConcept C158453852 @default.
- W2034502720 hasConcept C170493617 @default.
- W2034502720 hasConcept C198710026 @default.
- W2034502720 hasConcept C2778151854 @default.
- W2034502720 hasConcept C2778468042 @default.
- W2034502720 hasConcept C2780668150 @default.
- W2034502720 hasConcept C40465926 @default.
- W2034502720 hasConcept C71924100 @default.
- W2034502720 hasConcept C84393581 @default.
- W2034502720 hasConceptScore W2034502720C125567185 @default.
- W2034502720 hasConceptScore W2034502720C126322002 @default.
- W2034502720 hasConceptScore W2034502720C134018914 @default.
- W2034502720 hasConceptScore W2034502720C138976137 @default.
- W2034502720 hasConceptScore W2034502720C158453852 @default.
- W2034502720 hasConceptScore W2034502720C170493617 @default.
- W2034502720 hasConceptScore W2034502720C198710026 @default.
- W2034502720 hasConceptScore W2034502720C2778151854 @default.
- W2034502720 hasConceptScore W2034502720C2778468042 @default.
- W2034502720 hasConceptScore W2034502720C2780668150 @default.
- W2034502720 hasConceptScore W2034502720C40465926 @default.
- W2034502720 hasConceptScore W2034502720C71924100 @default.
- W2034502720 hasConceptScore W2034502720C84393581 @default.
- W2034502720 hasIssue "2" @default.
- W2034502720 hasLocation W20345027201 @default.
- W2034502720 hasLocation W20345027202 @default.
- W2034502720 hasOpenAccess W2034502720 @default.
- W2034502720 hasPrimaryLocation W20345027201 @default.
- W2034502720 hasRelatedWork W102105364 @default.
- W2034502720 hasRelatedWork W1977123261 @default.
- W2034502720 hasRelatedWork W2044747643 @default.
- W2034502720 hasRelatedWork W2047608102 @default.
- W2034502720 hasRelatedWork W2052453588 @default.
- W2034502720 hasRelatedWork W2077998387 @default.
- W2034502720 hasRelatedWork W2088924510 @default.
- W2034502720 hasRelatedWork W2091022983 @default.
- W2034502720 hasRelatedWork W2338962402 @default.
- W2034502720 hasRelatedWork W2418574610 @default.
- W2034502720 hasVolume "34" @default.
- W2034502720 isParatext "false" @default.
- W2034502720 isRetracted "false" @default.
- W2034502720 magId "2034502720" @default.
- W2034502720 workType "article" @default.