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- W2034503910 abstract "Vascular smooth muscle cells (SMC) play an important role in atherogenesis and vasospasm. Interferon-gamma (IFN-gamma) is a potent cytokine that regulates immune and inflammatory responses by inducing multiple genes in many types of cells including SMC. Retinoic acid-inducible gene-I (RIG-I) is a putative RNA helicase, but its physiological function is not known. RIG-I is induced in leukemic cells by retinoic acid or in endothelial cells by lipopolysaccharide. We have studied the expression of RIG-I in cultured SMC from human umbilical artery. IFN-gamma stimulated SMC to express RIG-I mRNA and protein in concentration- and time-dependent manners. Immunohistochemical analysis revealed the expression of RIG-I in SMC in vivo. We conclude that RIG-I may play some pathophysiological role in immune and inflammatory reactions in SMC." @default.
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- W2034503910 date "2004-07-01" @default.
- W2034503910 modified "2023-10-03" @default.
- W2034503910 title "Expression of retinoic acid-inducible gene-I in vascular smooth muscle cells stimulated with interferon-γ" @default.
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- W2034503910 doi "https://doi.org/10.1016/j.lfs.2004.01.030" @default.
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