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• W2034504579 abstract "A compilation of murine and human Ig H and TcR beta D segment sequences was used to estimate the relative usage of the various reading frames and to look for associated sequence patterns. We confirm a strong bias in the expression of the Ig H D segments, with more than 90% (murine) and 85% (human) expressed peptides resulting from a preferred reading frame. Remarkably, 86% (mouse) and 90% (human) of those peptides contain at least one glycine residue. All but one of the atypical preferred D peptides contain serine or proline residues and are found in the immediate vicinity of glycine residues provided by specific JH segments. The presence of tyrosine residues is also a characteristic feature of expressed reading frames in both mouse (75%) and human (90%). These results suggest that the constraints of forming a flexible loop within the third complementarity-determining region, is a factor in the preference for a particular reading frame in Ig H D. For the TcR beta D segments, glycine is specified in most reading frames, and no significant preference is observed." @default.
• W2034504579 created "2016-06-24" @default.
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• W2034504579 date "1991-12-01" @default.
• W2034504579 modified "2023-09-23" @default.
• W2034504579 title "A strong propensity toward loop formation characterizes the expressed reading frames of the D segments at the Ig H and T cell receptor loci" @default.
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• W2034504579 doi "https://doi.org/10.1002/eji.1830211218" @default.
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