FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034504872> ?p ?o ?g. }

• W2034504872 endingPage "154" @default.
• W2034504872 startingPage "144" @default.
• W2034504872 abstract "Summary. Conventional allogeneic stem cell transplantation (SCT) for myelodysplastic syndrome (MDS) is associated with excessive procedure‐related mortality. The outcome following volunteer‐unrelated donor (VUD) or sibling allogeneic SCT was therefore evaluated in 23 MDS patients conditioned with reduced‐intensity regimens (fludarabine/busulphan/Campath‐1H) because of advanced age (48 vs 37 years, P = 0·002) and/or co‐morbidity (19 vs 3, P < 0·0001) which precluded conventional transplantation, and compared with 29 treated with standard protocols [busulphan/cyclophosphamide (Bu/Cy); Bu/Cy/total‐body irradiation/Campath‐1G]. Graft‐versus‐host disease (GVHD) prophylaxis comprised of cyclosporine/methotrexate. One hundred per cent donor engraftment (variable number tandem repeat analysis/cytogenetics/fluorescence in situ hybridization) was achieved in 18/19 (95%) evaluable patients receiving reduced‐intensity regimens, although six (32%) have subsequently shown mixed chimaerism. Reduced‐intensity conditioning was associated with significantly reduced duration of aplasia, less mucositis, fever, antibiotic, analgesia, parenteral nutrition use, less acute and chronic GVHD, and lower early procedure‐related mortality [two (9%) vs nine (31%), P < 0·05]. Six patients relapsed (two standard, four reduced‐intensity) and two (reduced‐intensity) experienced late graft failure. The 2 year actuarial overall/disease‐free survival (OS/DFS) was 48/39% in the reduced‐intensity arm and 44/44% in the standard group. The 2 year non‐relapse mortality was 31% and 50% respectively. In VUD recipients, OS was superior in the reduced‐intensity arm (49% vs 34%). Predictors of DFS included good/intermediate‐risk karyotype, low/intermediate‐1 International Prognostic Scoring system score, human leucocyte antigen compatibility and attainment of complete remission. Our data demonstrates that VUD or sibling allogeneic SCT following reduced‐intensity conditioning is feasible in high‐risk MDS patients considered unsuitable for standard transplantation and is associated with comparable 3·5 year DFS to those receiving conventional regimens." @default.
• W2034504872 created "2016-06-24" @default.
• W2034504872 creator A5005456686 @default.
• W2034504872 creator A5013706725 @default.
• W2034504872 creator A5032585809 @default.
• W2034504872 creator A5033344593 @default.
• W2034504872 creator A5035489508 @default.
• W2034504872 creator A5057195638 @default.
• W2034504872 creator A5058120792 @default.
• W2034504872 creator A5062887160 @default.
• W2034504872 creator A5075026758 @default.
• W2034504872 creator A5081252933 @default.
• W2034504872 creator A5083452260 @default.
• W2034504872 creator A5083822738 @default.
• W2034504872 date "2002-10-01" @default.
• W2034504872 modified "2023-10-16" @default.
• W2034504872 title "Allogeneic stem cell transplantation in the myelodysplastic syndromes: interim results of outcome following reduced-intensity conditioning compared with standard preparative regimens" @default.
• W2034504872 cites W100647374 @default.
• W2034504872 cites W1479909146 @default.
• W2034504872 cites W1530764705 @default.
• W2034504872 cites W187238933 @default.
• W2034504872 cites W1879966002 @default.
• W2034504872 cites W1998688881 @default.
• W2034504872 cites W2025394831 @default.
• W2034504872 cites W2041292656 @default.
• W2034504872 cites W2053278212 @default.
• W2034504872 cites W2070614139 @default.
• W2034504872 cites W2278599555 @default.
• W2034504872 cites W2400458422 @default.
• W2034504872 cites W347010909 @default.
• W2034504872 cites W4246085869 @default.
• W2034504872 cites W85233391 @default.
• W2034504872 cites W9635739 @default.
• W2034504872 doi "https://doi.org/10.1046/j.1365-2141.2002.03796.x" @default.
• W2034504872 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12358919" @default.
• W2034504872 hasPublicationYear "2002" @default.
• W2034504872 type Work @default.
• W2034504872 sameAs 2034504872 @default.
• W2034504872 citedByCount "84" @default.
• W2034504872 countsByYear W20345048722013 @default.
• W2034504872 countsByYear W20345048722014 @default.
• W2034504872 countsByYear W20345048722015 @default.
• W2034504872 countsByYear W20345048722018 @default.
• W2034504872 countsByYear W20345048722019 @default.
• W2034504872 countsByYear W20345048722022 @default.
• W2034504872 crossrefType "journal-article" @default.
• W2034504872 hasAuthorship W2034504872A5005456686 @default.
• W2034504872 hasAuthorship W2034504872A5013706725 @default.
• W2034504872 hasAuthorship W2034504872A5032585809 @default.
• W2034504872 hasAuthorship W2034504872A5033344593 @default.
• W2034504872 hasAuthorship W2034504872A5035489508 @default.
• W2034504872 hasAuthorship W2034504872A5057195638 @default.
• W2034504872 hasAuthorship W2034504872A5058120792 @default.
• W2034504872 hasAuthorship W2034504872A5062887160 @default.
• W2034504872 hasAuthorship W2034504872A5075026758 @default.
• W2034504872 hasAuthorship W2034504872A5081252933 @default.
• W2034504872 hasAuthorship W2034504872A5083452260 @default.
• W2034504872 hasAuthorship W2034504872A5083822738 @default.
• W2034504872 hasConcept C126322002 @default.
• W2034504872 hasConcept C141071460 @default.
• W2034504872 hasConcept C2776694085 @default.
• W2034504872 hasConcept C2776755627 @default.
• W2034504872 hasConcept C2777408962 @default.
• W2034504872 hasConcept C2778496288 @default.
• W2034504872 hasConcept C2778880498 @default.
• W2034504872 hasConcept C2779015954 @default.
• W2034504872 hasConcept C2779263901 @default.
• W2034504872 hasConcept C2780007613 @default.
• W2034504872 hasConcept C2780611847 @default.
• W2034504872 hasConcept C2780817109 @default.
• W2034504872 hasConcept C2781059491 @default.
• W2034504872 hasConcept C2911091166 @default.
• W2034504872 hasConcept C71924100 @default.
• W2034504872 hasConcept C90924648 @default.
• W2034504872 hasConceptScore W2034504872C126322002 @default.
• W2034504872 hasConceptScore W2034504872C141071460 @default.
• W2034504872 hasConceptScore W2034504872C2776694085 @default.
• W2034504872 hasConceptScore W2034504872C2776755627 @default.
• W2034504872 hasConceptScore W2034504872C2777408962 @default.
• W2034504872 hasConceptScore W2034504872C2778496288 @default.
• W2034504872 hasConceptScore W2034504872C2778880498 @default.
• W2034504872 hasConceptScore W2034504872C2779015954 @default.
• W2034504872 hasConceptScore W2034504872C2779263901 @default.
• W2034504872 hasConceptScore W2034504872C2780007613 @default.
• W2034504872 hasConceptScore W2034504872C2780611847 @default.
• W2034504872 hasConceptScore W2034504872C2780817109 @default.
• W2034504872 hasConceptScore W2034504872C2781059491 @default.
• W2034504872 hasConceptScore W2034504872C2911091166 @default.
• W2034504872 hasConceptScore W2034504872C71924100 @default.
• W2034504872 hasConceptScore W2034504872C90924648 @default.
• W2034504872 hasIssue "1" @default.
• W2034504872 hasLocation W20345048721 @default.
• W2034504872 hasLocation W20345048722 @default.
• W2034504872 hasOpenAccess W2034504872 @default.
• W2034504872 hasPrimaryLocation W20345048721 @default.
• W2034504872 hasRelatedWork W1266631045 @default.
• W2034504872 hasRelatedWork W1894631610 @default.
• W2034504872 hasRelatedWork W2043565151 @default.

• next