FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034505789> ?p ?o ?g. }

• W2034505789 endingPage "232.e6" @default.
• W2034505789 startingPage "232.e1" @default.
• W2034505789 abstract "Objective To evaluate the role of gender in hepatic oxidative stress response and production of inflammatory cytokines in acute uremia after bilateral nephrectomy. Published studies indicate that the severity of tissue damage in kidney, brain, or heart injury may differ according to gender. We recently demonstrated that acute renal failure after kidney injury or bilateral nephrectomy activates oxidative stress and causes damage to the liver. Methods Male and female rats were subjected to bilateral nephrectomy and euthanized four hours later. Serum and liver tissues were collected and analyzed. To ascertain the role of testosterone and estrogen in hepatic oxidative stress, castration was carried out 15 days before bilateral nephrectomy. In some groups, animals were administrated 17-β-estradiol or vehicle for 2 weeks before bilateral nephrectomy. Results Hepatic oxidative stress was significantly pronounced in male rats as determined by increase in malondialdehyde (MDA) levels and decrease in total glutathione (GSH) contents. An increase in proinflammatory cytokine concentration was seen in male rats, whereas the antiinflammatory cytokine level was more elevated in females. Castration reduced hepatic oxidative stress and proinflammatory cytokine concentration, whereas exogenous estradiol after castration did not have an additional effect on these parameters. Conclusions There is a gender difference with regard to the severity of hepatic oxidative stress and inflammatory response in acute uremia after bilateral nephrectomy, with female rats displaying significant protection relative to male rats. We suggest that sex hormones could play an important role in the severity of remote tissue damage in acute kidney failure. To evaluate the role of gender in hepatic oxidative stress response and production of inflammatory cytokines in acute uremia after bilateral nephrectomy. Published studies indicate that the severity of tissue damage in kidney, brain, or heart injury may differ according to gender. We recently demonstrated that acute renal failure after kidney injury or bilateral nephrectomy activates oxidative stress and causes damage to the liver. Male and female rats were subjected to bilateral nephrectomy and euthanized four hours later. Serum and liver tissues were collected and analyzed. To ascertain the role of testosterone and estrogen in hepatic oxidative stress, castration was carried out 15 days before bilateral nephrectomy. In some groups, animals were administrated 17-β-estradiol or vehicle for 2 weeks before bilateral nephrectomy. Hepatic oxidative stress was significantly pronounced in male rats as determined by increase in malondialdehyde (MDA) levels and decrease in total glutathione (GSH) contents. An increase in proinflammatory cytokine concentration was seen in male rats, whereas the antiinflammatory cytokine level was more elevated in females. Castration reduced hepatic oxidative stress and proinflammatory cytokine concentration, whereas exogenous estradiol after castration did not have an additional effect on these parameters. There is a gender difference with regard to the severity of hepatic oxidative stress and inflammatory response in acute uremia after bilateral nephrectomy, with female rats displaying significant protection relative to male rats. We suggest that sex hormones could play an important role in the severity of remote tissue damage in acute kidney failure." @default.
• W2034505789 created "2016-06-24" @default.
• W2034505789 creator A5012803702 @default.
• W2034505789 creator A5034850101 @default.
• W2034505789 creator A5037874379 @default.
• W2034505789 creator A5077938189 @default.
• W2034505789 date "2011-07-01" @default.
• W2034505789 modified "2023-10-06" @default.
• W2034505789 title "Male Susceptibility to Hepatic Damage in Acute Uremia in Rats" @default.
• W2034505789 cites W130424530 @default.
• W2034505789 cites W1973590627 @default.
• W2034505789 cites W2007064404 @default.
• W2034505789 cites W2007656576 @default.
• W2034505789 cites W2014831771 @default.
• W2034505789 cites W2019978470 @default.
• W2034505789 cites W2032925403 @default.
• W2034505789 cites W2036109267 @default.
• W2034505789 cites W2037181103 @default.
• W2034505789 cites W2057954455 @default.
• W2034505789 cites W2077883762 @default.
• W2034505789 cites W2080557472 @default.
• W2034505789 cites W2094588541 @default.
• W2034505789 cites W2096320833 @default.
• W2034505789 cites W2113646992 @default.
• W2034505789 cites W2115564640 @default.
• W2034505789 cites W2118519973 @default.
• W2034505789 cites W2126157581 @default.
• W2034505789 cites W2131782993 @default.
• W2034505789 cites W2135398566 @default.
• W2034505789 cites W2139709054 @default.
• W2034505789 cites W2155321540 @default.
• W2034505789 cites W2157450955 @default.
• W2034505789 cites W2171234367 @default.
• W2034505789 cites W2187319204 @default.
• W2034505789 cites W969915667 @default.
• W2034505789 doi "https://doi.org/10.1016/j.urology.2011.03.028" @default.
• W2034505789 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21601256" @default.
• W2034505789 hasPublicationYear "2011" @default.
• W2034505789 type Work @default.
• W2034505789 sameAs 2034505789 @default.
• W2034505789 citedByCount "4" @default.
• W2034505789 countsByYear W20345057892013 @default.
• W2034505789 countsByYear W20345057892014 @default.
• W2034505789 countsByYear W20345057892017 @default.
• W2034505789 crossrefType "journal-article" @default.
• W2034505789 hasAuthorship W2034505789A5012803702 @default.
• W2034505789 hasAuthorship W2034505789A5034850101 @default.
• W2034505789 hasAuthorship W2034505789A5037874379 @default.
• W2034505789 hasAuthorship W2034505789A5077938189 @default.
• W2034505789 hasConcept C126322002 @default.
• W2034505789 hasConcept C134018914 @default.
• W2034505789 hasConcept C164027704 @default.
• W2034505789 hasConcept C2776151105 @default.
• W2034505789 hasConcept C2776635150 @default.
• W2034505789 hasConcept C2776914184 @default.
• W2034505789 hasConcept C2778401633 @default.
• W2034505789 hasConcept C2778690821 @default.
• W2034505789 hasConcept C2779256933 @default.
• W2034505789 hasConcept C2780091579 @default.
• W2034505789 hasConcept C2780227381 @default.
• W2034505789 hasConcept C2909276006 @default.
• W2034505789 hasConcept C71315377 @default.
• W2034505789 hasConcept C71924100 @default.
• W2034505789 hasConceptScore W2034505789C126322002 @default.
• W2034505789 hasConceptScore W2034505789C134018914 @default.
• W2034505789 hasConceptScore W2034505789C164027704 @default.
• W2034505789 hasConceptScore W2034505789C2776151105 @default.
• W2034505789 hasConceptScore W2034505789C2776635150 @default.
• W2034505789 hasConceptScore W2034505789C2776914184 @default.
• W2034505789 hasConceptScore W2034505789C2778401633 @default.
• W2034505789 hasConceptScore W2034505789C2778690821 @default.
• W2034505789 hasConceptScore W2034505789C2779256933 @default.
• W2034505789 hasConceptScore W2034505789C2780091579 @default.
• W2034505789 hasConceptScore W2034505789C2780227381 @default.
• W2034505789 hasConceptScore W2034505789C2909276006 @default.
• W2034505789 hasConceptScore W2034505789C71315377 @default.
• W2034505789 hasConceptScore W2034505789C71924100 @default.
• W2034505789 hasFunder F4320322670 @default.
• W2034505789 hasFunder F4320337357 @default.
• W2034505789 hasIssue "1" @default.
• W2034505789 hasLocation W20345057891 @default.
• W2034505789 hasLocation W20345057892 @default.
• W2034505789 hasOpenAccess W2034505789 @default.
• W2034505789 hasPrimaryLocation W20345057891 @default.
• W2034505789 hasRelatedWork W2003814064 @default.
• W2034505789 hasRelatedWork W2011120019 @default.
• W2034505789 hasRelatedWork W2027210979 @default.
• W2034505789 hasRelatedWork W2030751817 @default.
• W2034505789 hasRelatedWork W2076924632 @default.
• W2034505789 hasRelatedWork W2126288161 @default.
• W2034505789 hasRelatedWork W2155643750 @default.
• W2034505789 hasRelatedWork W2319873196 @default.
• W2034505789 hasRelatedWork W2981985604 @default.
• W2034505789 hasRelatedWork W2291436887 @default.
• W2034505789 hasVolume "78" @default.
• W2034505789 isParatext "false" @default.
• W2034505789 isRetracted "false" @default.
• W2034505789 magId "2034505789" @default.

• next