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• W2034506907 endingPage "335" @default.
• W2034506907 startingPage "315" @default.
• W2034506907 abstract "Prospective delineation of viable from nonviable myocardium in patients with coronary artery disease is an important factor in deciding whether a patient should be revascularized or treated medically. Two common techniques — single-photon emission computed tomography (SPECT) and positron-emission tomography (PET)—are used in nuclear medicine using various radiopharmaceuticals for the detection of myocardial viability in patients. Thallium-201 (201TI) and technetium-99m (99mTc)-sestamibi are the common radiopharmaceuticals used in different protocols using SPECT, whereas fluoride-18 (18F)-fluorodeoxyglucose (FDG) and rubidium-82 (82Rb) are most widely used in PET. the SPECT protocols involve stress/redistribution, stress/redistribution/reinjection, and rest/redistribution imaging techniques. Many studies have compared the results of 201TI and (99mTc)-sestamibi SPECT with those of FDG PET; in some studies, concordant results have been found between delayed thallium and FDG results, indicating that 201TI, although considered a perfusion agent, shows myocardial viability. Discordant results in a number of studies have been found between sestamibi and FDG, suggesting that the efficacy of sestamibi as a viability marker has yet to be established. Radiolabeled fatty acids such as iodine-123 (123I)-para-iodophenylpentadecanoic acid and carbon-11 (11C)-palmitic acid have been used for the assessment of myocardial viability with limited success. 11C-labeled acetate is a good marker of oxidative metabolism in the heart and has been used to predict the reversibility of wall motion abnormalities. (18F)-FDG is considered the marker of choice for myocardial viability, although variable results are obtained under different physiological conditions. Detection of myocardial viability can be greatly improved by developing new equipment and radiopharmaceuticals of better quality." @default.
• W2034506907 created "2016-06-24" @default.
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• W2034506907 date "1996-10-01" @default.
• W2034506907 modified "2023-09-27" @default.
• W2034506907 title "Present assessment of myocardial viability by nuclear imaging" @default.
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• W2034506907 doi "https://doi.org/10.1016/s0001-2998(96)80007-9" @default.
• W2034506907 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8916320" @default.
• W2034506907 hasPublicationYear "1996" @default.
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