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- W2034525381 abstract "Background: Tigecycline (TIG) has potent expanded broad spectrum activity against most commonly encountered species responsible for community and hospital acquired infections. The T.E.S.T. program determined the in vitro activity of TIG against Acinetobacter resistant to one or more of piperacillin-tazobactam (PT), levofloxacin (LVX), ceftriaxone (CAX), cefepime (CPE), amikacin (AK), minocycline (MIN), ceftazidime (CAZ), and imipenem (IMP). Study strains were collected from hospitals in the United States from 2004–2007. Methods: A total of 2,367 clinical isolates were identified to species level from participating sites and confirmed by the central laboratory. Minimum Inhibitory Concentrations (MICs) were determined by the local laboratory using supplied broth microdilution panels and interpreted according to CLSI guidelines Results: Resistance rates for comparator drugs were CAZ 42%, CAX 41%, LVX 41%, CPE 34%, PT 17%, AK 7%, MIN 7%, and IMP 2%. TIG inhibited 98% of all isolates at = 8 mcg/ml. TIG MIC50/90 for strains resistant to 0, 1, 2, 3, 4, or ≥5 drug classes were 0.12/0.5, 0.5/1, 0.5/2, 1/2, 1/2, and 1/4, respectively, demonstrating a gradual diminishment of TIG activity in strains resistant to multiple drug classes Conclusions: TIG had good in vitro activity against most Acinetobacter strains resistant to one or more other drugs in this study, although the higher TIG MICs seen for these strains suggests some linkage to resistance mechanisms for other drugs (efflux). TIG remained effective in inhibiting multi-drug resistant Acinetobacter spp., further demonstrating its wide spectrum of activity vs. drug-resistant bacteria." @default.
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- W2034525381 date "2008-12-01" @default.
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- W2034525381 title "Evaluation of Tigecycline in the United States Against Antimicrobial Resistant Acinetobacter" @default.
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- W2034525381 doi "https://doi.org/10.1016/j.ijid.2008.05.1077" @default.
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