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• W2034531634 abstract "Many autoantigens have been identified in human patients and in rodent models. In numerous experimental settings, these autoantigens or related autoreactive lymphocytes can transfer autoimmunity. Although autoreactivity spreads to new epitopes during the course of disease, single-epitope-specific therapies show considerable efficacy in multi-epitope-induced models of autoimmunity. These observations may indicate that epitope-specific therapies operate at the level of regulating mechanisms of immune tolerance rather than exerting a direct effect on autoreactive T lymphocytes." @default.
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• W2034531634 date "2000-12-01" @default.
• W2034531634 modified "2023-09-24" @default.
• W2034531634 title "The role of autoantigens in autoimmune disease" @default.
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• W2034531634 doi "https://doi.org/10.1016/s0952-7915(00)00169-2" @default.
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