FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034532011> ?p ?o ?g. }

• W2034532011 endingPage "27145" @default.
• W2034532011 startingPage "27134" @default.
• W2034532011 abstract "Mitochondria are highly dynamic organelles, and mitochondrial fission is a crucial step of apoptosis. Although Oma1 is believed to be responsible for long form Opa1 (L-Opa1) processing during mitochondrial fragmentation, whether and how Oma1 is involved in L-Opa1 processing and participates in the regulation of chemoresistance is unknown. Chemosensitive and chemoresistant ovarian (OVCA) and cervical (CECA) cancer cells were treated with cisplatin (CDDP). Mitochondrial dynamics and protein contents were assessed by immunofluorescence and Western blot, respectively. The requirements of Oma1 and p53 for CDDP-induced L-Opa1 processing, mitochondrial fragmentation, and apoptosis were examined by siRNA or cDNA. CDDP induces L-Opa1 processing and mitochondrial fragmentation in chemosensitive but not in chemoresistant cells. CDDP induced Oma1 40-kDa form increases in OV2008 cells, not in C13* cells. Oma1 knockdown inhibited L-Opa1 processing, mitochondrial fragmentation, and apoptosis. Silencing p53 expression attenuated the effects of CDDP in Oma1 (40 kDa) increase, L-Opa1 processing, mitochondrial fragmentation, and apoptosis in chemosensitive OVCA cells, whereas reconstitution of p53 in p53 mutant or null chemoresistant OVCA cells induced Oma1 (40 kDa) increase, L-Opa1 processing, mitochondrial fragmentation, and apoptosis irrespective of the presence of CDDP. Prohibitin 1 (Phb1) dissociates from Opa1-Phb1 complex and binds phosphorylated p53 (serine 15) in response to CDDP in chemosensitive but not chemoresistant CECA cells. These findings demonstrate that (a) p53 and Oma1 mediate L-Opa1 processing, (b) mitochondrial fragmentation is involved in CDDP-induced apoptosis in OVCA and CECA cells, and (c) dysregulated mitochondrial dynamics may in part be involved in the pathophysiology of CDDP resistance." @default.
• W2034532011 created "2016-06-24" @default.
• W2034532011 creator A5013170437 @default.
• W2034532011 creator A5015195367 @default.
• W2034532011 creator A5025314440 @default.
• W2034532011 creator A5027284603 @default.
• W2034532011 creator A5036694706 @default.
• W2034532011 date "2014-09-01" @default.
• W2034532011 modified "2023-10-16" @default.
• W2034532011 title "p53 Is Required for Cisplatin-induced Processing of the Mitochondrial Fusion Protein L-Opa1 That Is Mediated by the Mitochondrial Metallopeptidase Oma1 in Gynecologic Cancers" @default.
• W2034532011 cites W1970248089 @default.
• W2034532011 cites W1984695384 @default.
• W2034532011 cites W1989560849 @default.
• W2034532011 cites W1990832023 @default.
• W2034532011 cites W1999224816 @default.
• W2034532011 cites W2006091414 @default.
• W2034532011 cites W2006787533 @default.
• W2034532011 cites W2009278410 @default.
• W2034532011 cites W2014115155 @default.
• W2034532011 cites W2015594876 @default.
• W2034532011 cites W2020329223 @default.
• W2034532011 cites W2023373433 @default.
• W2034532011 cites W2033189241 @default.
• W2034532011 cites W2036404408 @default.
• W2034532011 cites W2037064466 @default.
• W2034532011 cites W2041061895 @default.
• W2034532011 cites W2049499974 @default.
• W2034532011 cites W2051239163 @default.
• W2034532011 cites W2064080426 @default.
• W2034532011 cites W2074341964 @default.
• W2034532011 cites W2076941428 @default.
• W2034532011 cites W2078793932 @default.
• W2034532011 cites W2086764184 @default.
• W2034532011 cites W2093406384 @default.
• W2034532011 cites W2104979289 @default.
• W2034532011 cites W2105043890 @default.
• W2034532011 cites W2106771830 @default.
• W2034532011 cites W2107277218 @default.
• W2034532011 cites W2111626525 @default.
• W2034532011 cites W2119434925 @default.
• W2034532011 cites W2138760860 @default.
• W2034532011 cites W2139636031 @default.
• W2034532011 cites W2168310850 @default.
• W2034532011 doi "https://doi.org/10.1074/jbc.m114.594812" @default.
• W2034532011 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4175349" @default.
• W2034532011 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25112877" @default.
• W2034532011 hasPublicationYear "2014" @default.
• W2034532011 type Work @default.
• W2034532011 sameAs 2034532011 @default.
• W2034532011 citedByCount "78" @default.
• W2034532011 countsByYear W20345320112015 @default.
• W2034532011 countsByYear W20345320112016 @default.
• W2034532011 countsByYear W20345320112017 @default.
• W2034532011 countsByYear W20345320112018 @default.
• W2034532011 countsByYear W20345320112019 @default.
• W2034532011 countsByYear W20345320112020 @default.
• W2034532011 countsByYear W20345320112021 @default.
• W2034532011 countsByYear W20345320112022 @default.
• W2034532011 countsByYear W20345320112023 @default.
• W2034532011 crossrefType "journal-article" @default.
• W2034532011 hasAuthorship W2034532011A5013170437 @default.
• W2034532011 hasAuthorship W2034532011A5015195367 @default.
• W2034532011 hasAuthorship W2034532011A5025314440 @default.
• W2034532011 hasAuthorship W2034532011A5027284603 @default.
• W2034532011 hasAuthorship W2034532011A5036694706 @default.
• W2034532011 hasBestOaLocation W20345320111 @default.
• W2034532011 hasConcept C104317684 @default.
• W2034532011 hasConcept C146587185 @default.
• W2034532011 hasConcept C153911025 @default.
• W2034532011 hasConcept C163950672 @default.
• W2034532011 hasConcept C17619807 @default.
• W2034532011 hasConcept C18903297 @default.
• W2034532011 hasConcept C190283241 @default.
• W2034532011 hasConcept C191015642 @default.
• W2034532011 hasConcept C24586158 @default.
• W2034532011 hasConcept C2775894526 @default.
• W2034532011 hasConcept C2776694085 @default.
• W2034532011 hasConcept C2777092462 @default.
• W2034532011 hasConcept C2778239845 @default.
• W2034532011 hasConcept C2779058106 @default.
• W2034532011 hasConcept C28859421 @default.
• W2034532011 hasConcept C31573885 @default.
• W2034532011 hasConcept C43759708 @default.
• W2034532011 hasConcept C502942594 @default.
• W2034532011 hasConcept C54355233 @default.
• W2034532011 hasConcept C547475151 @default.
• W2034532011 hasConcept C55493867 @default.
• W2034532011 hasConcept C86803240 @default.
• W2034532011 hasConcept C95444343 @default.
• W2034532011 hasConceptScore W2034532011C104317684 @default.
• W2034532011 hasConceptScore W2034532011C146587185 @default.
• W2034532011 hasConceptScore W2034532011C153911025 @default.
• W2034532011 hasConceptScore W2034532011C163950672 @default.
• W2034532011 hasConceptScore W2034532011C17619807 @default.
• W2034532011 hasConceptScore W2034532011C18903297 @default.
• W2034532011 hasConceptScore W2034532011C190283241 @default.
• W2034532011 hasConceptScore W2034532011C191015642 @default.
• W2034532011 hasConceptScore W2034532011C24586158 @default.

• next