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- W2034539239 abstract "This paper presents a compact model of the role of transposable elements in eucaryote evolution which, although forward looking, is consistent with both experimental results and theories of gene regulation. The model postulates that a principal factor in the emergence of the eucaryotes was the development of a symbiotic relationship between reverse transcribing transposable elements and RNA based gene regulation, which we will call structural symbiosis. Thus, although transposable elements follow their own evolutionary protocol, structural homologies between cellular and viral genomes result in selective mutagenesis, a situation where transposon mutations are permitted because they can result in phenotypic mutations of the regulatory process with reduced probability of deleterious mutation of structural genes. The incorporation of this scheme into the life cycle of higher organisms results in two forms of integral evolution. Exogenous, in which differing species in an ecosystem share genetic information through viral transfer, and endogenous in which somatically induced regulatory mutations can be mapped back into the germ line." @default.
- W2034539239 created "2016-06-24" @default.
- W2034539239 creator A5047612599 @default.
- W2034539239 date "1985-06-01" @default.
- W2034539239 modified "2023-09-26" @default.
- W2034539239 title "A model for transposon-based eucaryote regulatory evolution" @default.
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- W2034539239 doi "https://doi.org/10.1016/s0022-5193(85)80178-8" @default.
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