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• W2034546426 abstract "Autoimmune diseases represent a heterogeneous group of conditions whose incidence is increasing worldwide. This has stimulated studies on their etiopathogenesis, derived from a complex interaction between genetic and environmental factors, aimed at finally improving prevention and treatment of these diseases. In the autoimmune process, immune responses are generated against self antigens presented by Major Histocompatibility Complex (MHC) class I on the cell surface. These peptide/MHC class I complexes are generated and assembled through MHC class I antigen processing and presentation machinery. In the endoplasmic reticulum (ER), aminopeptidases ERAP1 and ERAP2 display distinct trimming activity before antigenic peptides are loaded onto MHC class I molecules. The advent of new tools such as genome-wide association studies (GWAS) has provided evidence for new susceptibility loci and candidate genes playing a role in the autoimmune process for the recognized immune function of their transcripts. Genetic linkage has been discovered with MHC antigens and various autoimmune conditions. Recent GWAS showed the importance of ERAP1 and ERAP2 in several autoimmune diseases, including ankylosing spondylitis, insulin-dependent diabetes mellitus, psoriasis, multiple sclerosis, Crohn's disease. In this review, we first provide a general overview of ERAP1 and ERAP2 genes, their biological functions and their relevancy in autoimmunity. We then discuss the importance of GWAS and the case-control studies that confirm the relevancy of ERAP single-nucleotide polymorphism associations and their linkage with particular MHC class I haplotypes, supporting a putative functional role in the autoimmune process." @default.
• W2034546426 created "2016-06-24" @default.
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• W2034546426 creator A5022712318 @default.
• W2034546426 creator A5068233343 @default.
• W2034546426 creator A5086984377 @default.
• W2034546426 date "2012-12-01" @default.
• W2034546426 modified "2023-09-27" @default.
• W2034546426 title "The putative role of endoplasmic reticulum aminopeptidases in autoimmunity: Insights from genomic-wide association studies" @default.
• W2034546426 cites W1509776726 @default.
• W2034546426 cites W1553877174 @default.
• W2034546426 cites W1587563234 @default.
• W2034546426 cites W1595909653 @default.
• W2034546426 cites W1608008200 @default.
• W2034546426 cites W1809576401 @default.
• W2034546426 cites W1825388809 @default.
• W2034546426 cites W1964156630 @default.
• W2034546426 cites W1974968151 @default.
• W2034546426 cites W1978601549 @default.
• W2034546426 cites W1981338942 @default.
• W2034546426 cites W1981714996 @default.
• W2034546426 cites W1981924240 @default.
• W2034546426 cites W1996998447 @default.
• W2034546426 cites W1997400032 @default.
• W2034546426 cites W2004267572 @default.
• W2034546426 cites W2008437008 @default.
• W2034546426 cites W2009794923 @default.
• W2034546426 cites W2011330261 @default.
• W2034546426 cites W2011450045 @default.
• W2034546426 cites W2015391699 @default.
• W2034546426 cites W2015516540 @default.
• W2034546426 cites W2016656647 @default.
• W2034546426 cites W2017893786 @default.
• W2034546426 cites W2019357085 @default.
• W2034546426 cites W2021174967 @default.
• W2034546426 cites W2027372853 @default.
• W2034546426 cites W2027676104 @default.
• W2034546426 cites W2028267776 @default.
• W2034546426 cites W2033605807 @default.
• W2034546426 cites W2036533488 @default.
• W2034546426 cites W2039542333 @default.
• W2034546426 cites W2041668368 @default.
• W2034546426 cites W2042569235 @default.
• W2034546426 cites W2044841060 @default.
• W2034546426 cites W2046579578 @default.
• W2034546426 cites W2049572499 @default.
• W2034546426 cites W2050823809 @default.
• W2034546426 cites W2050944927 @default.
• W2034546426 cites W2053779737 @default.
• W2034546426 cites W2057021155 @default.
• W2034546426 cites W2061446718 @default.
• W2034546426 cites W2064475079 @default.
• W2034546426 cites W2073621589 @default.
• W2034546426 cites W2076595626 @default.
• W2034546426 cites W2076780748 @default.
• W2034546426 cites W2079135878 @default.
• W2034546426 cites W2079175701 @default.
• W2034546426 cites W2084606929 @default.
• W2034546426 cites W2088364573 @default.
• W2034546426 cites W2092413492 @default.
• W2034546426 cites W2092836731 @default.
• W2034546426 cites W2096809569 @default.
• W2034546426 cites W2099479709 @default.
• W2034546426 cites W2099580736 @default.
• W2034546426 cites W2101108806 @default.
• W2034546426 cites W2101806086 @default.
• W2034546426 cites W2105842551 @default.
• W2034546426 cites W2106779017 @default.
• W2034546426 cites W2109338462 @default.
• W2034546426 cites W2112415435 @default.
• W2034546426 cites W2118434625 @default.
• W2034546426 cites W2129387684 @default.
• W2034546426 cites W2134783591 @default.
• W2034546426 cites W2134802820 @default.
• W2034546426 cites W2135703966 @default.
• W2034546426 cites W2137647558 @default.
• W2034546426 cites W2139982131 @default.
• W2034546426 cites W2143669749 @default.
• W2034546426 cites W2145651018 @default.
• W2034546426 cites W2146173065 @default.
• W2034546426 cites W2153301367 @default.
• W2034546426 cites W2155755888 @default.
• W2034546426 cites W2156459362 @default.
• W2034546426 cites W2157285699 @default.
• W2034546426 cites W2159778991 @default.
• W2034546426 cites W2163126355 @default.
• W2034546426 cites W2163522157 @default.
• W2034546426 cites W2164392039 @default.
• W2034546426 cites W2165872127 @default.
• W2034546426 cites W2324450935 @default.
• W2034546426 cites W2326534029 @default.
• W2034546426 cites W2329494095 @default.
• W2034546426 cites W2561759163 @default.
• W2034546426 cites W4229497290 @default.
• W2034546426 cites W4249483860 @default.
• W2034546426 doi "https://doi.org/10.1016/j.autrev.2012.04.007" @default.
• W2034546426 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22575366" @default.
• W2034546426 hasPublicationYear "2012" @default.

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