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• W2034550136 abstract "In Parkinson's disease neuroprotective therapy to rescue dopamine neurons has been proposed. Selegiline is one of neuroprotective drug candidates, as proved by in vivo and in vitro experiments. In this paper, the mechanism underlying neuroprotection by selegiline and related propargylamines was studied against apoptosis induced by an endogenous toxin, N-methyl(R)salsolinol, synthetic 6-hydroxydopamine and peroxynitrite in dopaminergic SH-SY5Y cells. Propargylamines prevented apoptotic DNA damage, through suppression of collapse in mitochondrial membrane potential and following activation of caspase 3 and signal transduction to nuclei. These results suggest that propargylamines may rescue or protect dopamine neurons in Parkinson's disease." @default.
• W2034550136 created "2016-06-24" @default.
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• W2034550136 date "2001-10-01" @default.
• W2034550136 modified "2023-09-24" @default.
• W2034550136 title "Future of neuroprotection in Parkinson's disease" @default.
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• W2034550136 doi "https://doi.org/10.1016/s1353-8020(01)00028-1" @default.
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