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• W2034554278 endingPage "435" @default.
• W2034554278 startingPage "423" @default.
• W2034554278 abstract "Viral hemorrhagic fevers (VHFs) caused by Ebola, Marburg and Lassa viruses often manifest as multiple organ dysfunction and hemorrhagic shock with high mortality. These viruses target numerous cell types, including monocytes and dendritic cells, which are primary early targets that mediate critical pathogenetic processes. This review focuses on fibroblastic reticular cells (FRCs), another prevalent infected cell type that is known as a key regulator of circulatory and immune functions. Viral infection of FRCs could have debilitating effects in secondary lymphoid organs and various other tissues. FRCs may also contribute to the spread of these deadly viruses throughout the body. Here, we review the salient features of these VHFs and the biology of FRCs, emphasizing the potential role of these cells in VHFs and the rapid deterioration of immune and hemovascular sytems that are characteristic of such acute infections." @default.
• W2034554278 created "2016-06-24" @default.
• W2034554278 creator A5004481994 @default.
• W2034554278 creator A5024071568 @default.
• W2034554278 creator A5076873642 @default.
• W2034554278 date "2009-05-01" @default.
• W2034554278 modified "2023-10-02" @default.
• W2034554278 title "Fibroblastic reticular cells and their role in viral hemorrhagic fevers" @default.
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