Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034555465> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2034555465 endingPage "92" @default.
- W2034555465 startingPage "87" @default.
- W2034555465 abstract "The role of the L-arginine-NO pathway on the formation of PGE2 by cultured astroglial cells incubated with the HIV coating glycoprotein gp120 was investigated. Preincubation of human cultured T 67 astrocytoma cells with gp 120 (100-500 nM) produced a significant increase of nitrite (the breakdown product of NO) and PGE2 in cell supernatants. The effect of gp 120 on both nitrite and PGE2 production was antagonized by inhibition of NO synthase by L-NAME (20-300 μM). The inhibition of gp120-induced PGE2 production by L-NAME was reverted by addition of arachidonic acid (30 μM), an effect antagonized by the cyclo-oxygenase inhibitor indomethacin (10 μM). Methylen bleu, an inhibitor of the biological activity of NO acting at the guanylate cyclase level failed to affect gp 120-mediated PGE2, release showing that the increase of cGMP subsequent to NO production was not involved in the modulatory activity of NO on arachidonic acid cascade. On the basis of present experiments we conclude that gp120-induced release of PGE2 by astroglial cells is driven by NO, thereby contributing in the involvement of glial cells in HIV-related cerebral disorders." @default.
- W2034555465 created "2016-06-24" @default.
- W2034555465 creator A5006053315 @default.
- W2034555465 creator A5020321624 @default.
- W2034555465 creator A5026370741 @default.
- W2034555465 creator A5040339049 @default.
- W2034555465 creator A5043847254 @default.
- W2034555465 date "1994-08-01" @default.
- W2034555465 modified "2023-10-15" @default.
- W2034555465 title "HIV Coating gp 120 Glycoprotein-Dependent Prostaglandin-E2 Release by Human Cultured Astrocytoma Cells Is Regulated by Nitric Oxide Formation" @default.
- W2034555465 doi "https://doi.org/10.1006/bbrc.1994.2152" @default.
- W2034555465 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7521167" @default.
- W2034555465 hasPublicationYear "1994" @default.
- W2034555465 type Work @default.
- W2034555465 sameAs 2034555465 @default.
- W2034555465 citedByCount "26" @default.
- W2034555465 countsByYear W20345554652014 @default.
- W2034555465 countsByYear W20345554652015 @default.
- W2034555465 crossrefType "journal-article" @default.
- W2034555465 hasAuthorship W2034555465A5006053315 @default.
- W2034555465 hasAuthorship W2034555465A5020321624 @default.
- W2034555465 hasAuthorship W2034555465A5026370741 @default.
- W2034555465 hasAuthorship W2034555465A5040339049 @default.
- W2034555465 hasAuthorship W2034555465A5043847254 @default.
- W2034555465 hasConcept C108625454 @default.
- W2034555465 hasConcept C134018914 @default.
- W2034555465 hasConcept C153911025 @default.
- W2034555465 hasConcept C181199279 @default.
- W2034555465 hasConcept C185592680 @default.
- W2034555465 hasConcept C2777198256 @default.
- W2034555465 hasConcept C2777622882 @default.
- W2034555465 hasConcept C2777956040 @default.
- W2034555465 hasConcept C2778078955 @default.
- W2034555465 hasConcept C2780664492 @default.
- W2034555465 hasConcept C519581460 @default.
- W2034555465 hasConcept C54355233 @default.
- W2034555465 hasConcept C55493867 @default.
- W2034555465 hasConcept C81885089 @default.
- W2034555465 hasConcept C86803240 @default.
- W2034555465 hasConceptScore W2034555465C108625454 @default.
- W2034555465 hasConceptScore W2034555465C134018914 @default.
- W2034555465 hasConceptScore W2034555465C153911025 @default.
- W2034555465 hasConceptScore W2034555465C181199279 @default.
- W2034555465 hasConceptScore W2034555465C185592680 @default.
- W2034555465 hasConceptScore W2034555465C2777198256 @default.
- W2034555465 hasConceptScore W2034555465C2777622882 @default.
- W2034555465 hasConceptScore W2034555465C2777956040 @default.
- W2034555465 hasConceptScore W2034555465C2778078955 @default.
- W2034555465 hasConceptScore W2034555465C2780664492 @default.
- W2034555465 hasConceptScore W2034555465C519581460 @default.
- W2034555465 hasConceptScore W2034555465C54355233 @default.
- W2034555465 hasConceptScore W2034555465C55493867 @default.
- W2034555465 hasConceptScore W2034555465C81885089 @default.
- W2034555465 hasConceptScore W2034555465C86803240 @default.
- W2034555465 hasIssue "1" @default.
- W2034555465 hasLocation W20345554651 @default.
- W2034555465 hasLocation W20345554652 @default.
- W2034555465 hasOpenAccess W2034555465 @default.
- W2034555465 hasPrimaryLocation W20345554651 @default.
- W2034555465 hasRelatedWork W1939319907 @default.
- W2034555465 hasRelatedWork W1963578234 @default.
- W2034555465 hasRelatedWork W1978646997 @default.
- W2034555465 hasRelatedWork W1979081200 @default.
- W2034555465 hasRelatedWork W1990567068 @default.
- W2034555465 hasRelatedWork W1998991576 @default.
- W2034555465 hasRelatedWork W2013341230 @default.
- W2034555465 hasRelatedWork W2058026824 @default.
- W2034555465 hasRelatedWork W2091494117 @default.
- W2034555465 hasRelatedWork W2165501377 @default.
- W2034555465 hasVolume "203" @default.
- W2034555465 isParatext "false" @default.
- W2034555465 isRetracted "false" @default.
- W2034555465 magId "2034555465" @default.
- W2034555465 workType "article" @default.