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• W2034558308 abstract "The introduction of chalcone synthase A transgenes into petunia plants can result in degradation of chalcone synthase A RNAs and loss of chalcone synthase, a process called cosuppression or post-transcriptional gene silencing. Here we show that the RNA degradation is associated with changes in premRNA processing, i.e. loss of tissue specificity in transcript cleavage patterns, accumulation of unspliced molecules, and use of template-specific secondary poly(A) sites. These changes can also be observed at a lower level in leaves but not flowers of nontransgenic petunias. Based on this, a model is presented of how transgenes may disturb the carefully evolved, developmentally controlled post-transcriptional regulation of chalcone synthase gene expression by influencing the survival rate of the endogenous and their own mRNA." @default.
• W2034558308 created "2016-06-24" @default.
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• W2034558308 date "2000-07-01" @default.
• W2034558308 modified "2023-09-28" @default.
• W2034558308 title "Developmentally and transgene regulated nuclear processing of primary transcripts of chalcone synthase A in petunia" @default.
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• W2034558308 doi "https://doi.org/10.1046/j.1365-313x.2000.00793.x" @default.
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