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- W2034558341 abstract "Summary: Five patients with chronic obstructive lung disease associated with homozygous deficiency of alpha,-antitrypsin were found in an 18-month period at the Repatriation General Hospital, Concord. The lung function of these patients was studied in detail and the alpha,-antitrypsin levels and lung function of relatives of two of the patients were measured.The lung function results indicated the presence of severe emphysema in all patients and severe bronchitis in three of them. Abnormalities of lung function were found in all the asymptomatic relatives with homozygous and heterozygous deficiencies. These results, together with a review of the published results of lung function in people with homozygous deficiency indicate that in adults homozygous deficiency of alpha,-antitrypsin is always associated with abnormalities of lung function. Although some abnormality of lung function was found in all the relatives with heterozygous deficiency in the present study, it is not fully established if the hetero-zygous state is associated with an in-creased incidence of lung disease." @default.
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- W2034558341 date "1972-05-01" @default.
- W2034558341 modified "2023-10-18" @default.
- W2034558341 title "Pulmonary Function in Alpha,-Antitrypsin Deficiency" @default.
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- W2034558341 doi "https://doi.org/10.1111/j.1445-5994.1972.tb03926.x" @default.
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