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- W2034559071 abstract "The cis-AB phenotype can raise questions about an apparently paradoxical inheritance of the ABO blood group, such as the birth of an O child from an AB mother. These subtype ABO alleles confer the ability to create both A and B antigens with a single enzyme. A variety of different cis-AB enzymes have been reported and many feature an interchange of amino acids between the normal A enzyme sequence and its B counterpart, rendering the mutant enzyme capable of creating both antigens. The resulting red blood cells do not usually express A or B antigen at the same level that would be expected on common group A1 or B red blood cells, and the results of investigations into the kinetics of the cis-AB enzyme more clearly predict the extent of antigen expression. By correctly identifying the cis-AB phenotype, the blood bank can be of assistance to a clinician faced with a patient with what appears to be a genetically impossible ABO blood group." @default.
- W2034559071 created "2016-06-24" @default.
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- W2034559071 date "2006-07-01" @default.
- W2034559071 modified "2023-10-16" @default.
- W2034559071 title "The cis-AB Blood Group Phenotype: Fundamental Lessons in Glycobiology" @default.
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- W2034559071 doi "https://doi.org/10.1016/j.tmrv.2006.03.002" @default.
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