Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034559265> ?p ?o ?g. }
- W2034559265 endingPage "135" @default.
- W2034559265 startingPage "126" @default.
- W2034559265 abstract "At sites of vessel-wall injury, vascular smooth muscle cells (VSMCs) can dedifferentiate to express an invasive and proliferative phenotype, which contributes to the development of neointimal lesions and vascular disorders. Herein, we demonstrate that the loss of the VSMC differentiated phenotype, as the repression of contractile-protein expression, is correlated with a dramatic upregulation of the membrane-anchored matrix metalloproteinase MT1-MMP (also known as MMP14 and membrane-type 1 matrix metalloproteinase). Matrix metalloproteinase (MMP) inhibitors or MT1-MMP deficiency led to attenuated VSMC dedifferentiation, whereas the phenotypic switch was re-engaged following the restoration of MT1-MMP activity in MT1-MMP–/– cells. MT1-MMP-dependent dedifferentiation was mediated by the PDGF-BB–PDGFRβ pathway in parallel with the proteolytic processing of the multifunctional LDL receptor-related protein LRP1 and the dynamic internalization of a PDGFRβ–β3-integrin–MT1-MMP–LRP1 multi-component complex. Importantly, LRP1 silencing allowed the PDGF-BB-induced dedifferentiation program to proceed in the absence of MT1-MMP activity, supporting the role of unprocessed LRP1 as a gatekeeper of VSMC differentiation. Hence, MT1-MMP and LRP1 serve as a new effector–target-molecule axis that controls the PDGF-BB–PDGFRβ-dependent VSMC phenotype and function." @default.
- W2034559265 created "2016-06-24" @default.
- W2034559265 creator A5003121360 @default.
- W2034559265 creator A5016225667 @default.
- W2034559265 creator A5017530905 @default.
- W2034559265 creator A5080476399 @default.
- W2034559265 creator A5085029945 @default.
- W2034559265 date "2009-01-01" @default.
- W2034559265 modified "2023-09-27" @default.
- W2034559265 title "MT1-MMP promotes vascular smooth muscle dedifferentiation through LRP1 processing" @default.
- W2034559265 cites W1968084778 @default.
- W2034559265 cites W1970366992 @default.
- W2034559265 cites W1974824219 @default.
- W2034559265 cites W1978410998 @default.
- W2034559265 cites W1982711630 @default.
- W2034559265 cites W1983376590 @default.
- W2034559265 cites W1991693796 @default.
- W2034559265 cites W1994641823 @default.
- W2034559265 cites W2010254599 @default.
- W2034559265 cites W2016345457 @default.
- W2034559265 cites W2016484384 @default.
- W2034559265 cites W2029634948 @default.
- W2034559265 cites W2036135307 @default.
- W2034559265 cites W2048058951 @default.
- W2034559265 cites W2049806614 @default.
- W2034559265 cites W2051434743 @default.
- W2034559265 cites W2053587992 @default.
- W2034559265 cites W2057229979 @default.
- W2034559265 cites W2058354015 @default.
- W2034559265 cites W2058488557 @default.
- W2034559265 cites W2068561314 @default.
- W2034559265 cites W2071359561 @default.
- W2034559265 cites W2074005418 @default.
- W2034559265 cites W2074701223 @default.
- W2034559265 cites W2083420516 @default.
- W2034559265 cites W2083536576 @default.
- W2034559265 cites W2083712812 @default.
- W2034559265 cites W2089286878 @default.
- W2034559265 cites W2091506885 @default.
- W2034559265 cites W2099761715 @default.
- W2034559265 cites W2105599853 @default.
- W2034559265 cites W2107505404 @default.
- W2034559265 cites W2115810495 @default.
- W2034559265 cites W2121822802 @default.
- W2034559265 cites W2133913480 @default.
- W2034559265 cites W2139147914 @default.
- W2034559265 cites W2140563259 @default.
- W2034559265 cites W2144763197 @default.
- W2034559265 cites W2148923374 @default.
- W2034559265 cites W2151566330 @default.
- W2034559265 cites W2152845778 @default.
- W2034559265 cites W2160761045 @default.
- W2034559265 cites W2164965551 @default.
- W2034559265 cites W2166283169 @default.
- W2034559265 cites W2168116130 @default.
- W2034559265 cites W2169889638 @default.
- W2034559265 cites W3142447781 @default.
- W2034559265 cites W4377428302 @default.
- W2034559265 doi "https://doi.org/10.1242/jcs.035279" @default.
- W2034559265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19066283" @default.
- W2034559265 hasPublicationYear "2009" @default.
- W2034559265 type Work @default.
- W2034559265 sameAs 2034559265 @default.
- W2034559265 citedByCount "50" @default.
- W2034559265 countsByYear W20345592652012 @default.
- W2034559265 countsByYear W20345592652013 @default.
- W2034559265 countsByYear W20345592652014 @default.
- W2034559265 countsByYear W20345592652015 @default.
- W2034559265 countsByYear W20345592652016 @default.
- W2034559265 countsByYear W20345592652017 @default.
- W2034559265 countsByYear W20345592652019 @default.
- W2034559265 countsByYear W20345592652020 @default.
- W2034559265 countsByYear W20345592652021 @default.
- W2034559265 countsByYear W20345592652022 @default.
- W2034559265 countsByYear W20345592652023 @default.
- W2034559265 crossrefType "journal-article" @default.
- W2034559265 hasAuthorship W2034559265A5003121360 @default.
- W2034559265 hasAuthorship W2034559265A5016225667 @default.
- W2034559265 hasAuthorship W2034559265A5017530905 @default.
- W2034559265 hasAuthorship W2034559265A5080476399 @default.
- W2034559265 hasAuthorship W2034559265A5085029945 @default.
- W2034559265 hasConcept C104317684 @default.
- W2034559265 hasConcept C109523444 @default.
- W2034559265 hasConcept C119056186 @default.
- W2034559265 hasConcept C127561419 @default.
- W2034559265 hasConcept C127716648 @default.
- W2034559265 hasConcept C134018914 @default.
- W2034559265 hasConcept C139647698 @default.
- W2034559265 hasConcept C139770010 @default.
- W2034559265 hasConcept C170493617 @default.
- W2034559265 hasConcept C180361614 @default.
- W2034559265 hasConcept C189165786 @default.
- W2034559265 hasConcept C195687474 @default.
- W2034559265 hasConcept C2775960820 @default.
- W2034559265 hasConcept C2778163477 @default.
- W2034559265 hasConcept C2779395532 @default.
- W2034559265 hasConcept C2780072125 @default.
- W2034559265 hasConcept C2992686903 @default.