Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034588313> ?p ?o ?g. }
- W2034588313 endingPage "1138" @default.
- W2034588313 startingPage "1133" @default.
- W2034588313 abstract "The present study was aimed to investigate and compare the efficacy of duloxetine (DLX) loaded nanostructured lipid carriers (NLC) with DLX solution pharmacodynamically following intranasal administration. The study was further conducted to estimate DLX concentration in brain and blood. DLX was administered to albino Wistar rats either intranasally or orally in solution form (DLX solution) or encapsulated in NLC (DLX-NLC). These were evaluated in-vivo for pharmacodynamic studies for depression by forced swimming test and locomotor activity test. Intranasal DLX-NLC treatment exhibited improved behavioural analysis results (swimming, climbing, and immobility) than the DLX solution after 24 h of study. Furthermore, DLX-NLC significantly increased the total swimming and climbing time when compared with control and significantly reduced the immobility period. The intranasal DLX-NLC demonstrated improved locomotor activity when compared with DLX solution. Amount of DLX was quantified in blood and brain after the forced swimming test. The intranasal DLX-NLC demonstrated higher concentration in brain compared with DLX solution. Thus, intranasal DLX-NLC was found to be a promising formulation for the treatment of depression." @default.
- W2034588313 created "2016-06-24" @default.
- W2034588313 creator A5007431624 @default.
- W2034588313 creator A5025737605 @default.
- W2034588313 creator A5026410761 @default.
- W2034588313 creator A5068029500 @default.
- W2034588313 creator A5069797578 @default.
- W2034588313 creator A5077599012 @default.
- W2034588313 date "2012-09-01" @default.
- W2034588313 modified "2023-10-16" @default.
- W2034588313 title "Intranasal administration of nanostructured lipid carriers containing CNS acting drug: Pharmacodynamic studies and estimation in blood and brain" @default.
- W2034588313 cites W1501777540 @default.
- W2034588313 cites W1963522531 @default.
- W2034588313 cites W1966420953 @default.
- W2034588313 cites W1971082829 @default.
- W2034588313 cites W1974471610 @default.
- W2034588313 cites W1982721912 @default.
- W2034588313 cites W1996166611 @default.
- W2034588313 cites W2007893172 @default.
- W2034588313 cites W2016864853 @default.
- W2034588313 cites W2023868265 @default.
- W2034588313 cites W2025418692 @default.
- W2034588313 cites W2031483215 @default.
- W2034588313 cites W2033980704 @default.
- W2034588313 cites W2037909938 @default.
- W2034588313 cites W2038622171 @default.
- W2034588313 cites W2051372812 @default.
- W2034588313 cites W2054189154 @default.
- W2034588313 cites W2054349797 @default.
- W2034588313 cites W2056812747 @default.
- W2034588313 cites W2062652730 @default.
- W2034588313 cites W2070703400 @default.
- W2034588313 cites W2071211938 @default.
- W2034588313 cites W2077756131 @default.
- W2034588313 cites W2081337060 @default.
- W2034588313 cites W2082301887 @default.
- W2034588313 cites W2083571917 @default.
- W2034588313 cites W2089299823 @default.
- W2034588313 cites W2091064555 @default.
- W2034588313 cites W2093918270 @default.
- W2034588313 cites W2113945122 @default.
- W2034588313 cites W2120833124 @default.
- W2034588313 cites W2132050189 @default.
- W2034588313 cites W2146413877 @default.
- W2034588313 cites W2156339880 @default.
- W2034588313 cites W2156946852 @default.
- W2034588313 cites W2331713002 @default.
- W2034588313 cites W4237395977 @default.
- W2034588313 doi "https://doi.org/10.1016/j.jpsychires.2012.05.014" @default.
- W2034588313 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22749490" @default.
- W2034588313 hasPublicationYear "2012" @default.
- W2034588313 type Work @default.
- W2034588313 sameAs 2034588313 @default.
- W2034588313 citedByCount "65" @default.
- W2034588313 countsByYear W20345883132013 @default.
- W2034588313 countsByYear W20345883132014 @default.
- W2034588313 countsByYear W20345883132015 @default.
- W2034588313 countsByYear W20345883132016 @default.
- W2034588313 countsByYear W20345883132017 @default.
- W2034588313 countsByYear W20345883132018 @default.
- W2034588313 countsByYear W20345883132019 @default.
- W2034588313 countsByYear W20345883132020 @default.
- W2034588313 countsByYear W20345883132021 @default.
- W2034588313 countsByYear W20345883132022 @default.
- W2034588313 countsByYear W20345883132023 @default.
- W2034588313 crossrefType "journal-article" @default.
- W2034588313 hasAuthorship W2034588313A5007431624 @default.
- W2034588313 hasAuthorship W2034588313A5025737605 @default.
- W2034588313 hasAuthorship W2034588313A5026410761 @default.
- W2034588313 hasAuthorship W2034588313A5068029500 @default.
- W2034588313 hasAuthorship W2034588313A5069797578 @default.
- W2034588313 hasAuthorship W2034588313A5077599012 @default.
- W2034588313 hasConcept C111113717 @default.
- W2034588313 hasConcept C112705442 @default.
- W2034588313 hasConcept C71924100 @default.
- W2034588313 hasConcept C85663871 @default.
- W2034588313 hasConcept C98274493 @default.
- W2034588313 hasConceptScore W2034588313C111113717 @default.
- W2034588313 hasConceptScore W2034588313C112705442 @default.
- W2034588313 hasConceptScore W2034588313C71924100 @default.
- W2034588313 hasConceptScore W2034588313C85663871 @default.
- W2034588313 hasConceptScore W2034588313C98274493 @default.
- W2034588313 hasIssue "9" @default.
- W2034588313 hasLocation W20345883131 @default.
- W2034588313 hasLocation W20345883132 @default.
- W2034588313 hasOpenAccess W2034588313 @default.
- W2034588313 hasPrimaryLocation W20345883131 @default.
- W2034588313 hasRelatedWork W2011632803 @default.
- W2034588313 hasRelatedWork W2040601399 @default.
- W2034588313 hasRelatedWork W2356473259 @default.
- W2034588313 hasRelatedWork W2416467098 @default.
- W2034588313 hasRelatedWork W2619054893 @default.
- W2034588313 hasRelatedWork W2926167513 @default.
- W2034588313 hasRelatedWork W3025109127 @default.
- W2034588313 hasRelatedWork W4245054046 @default.
- W2034588313 hasRelatedWork W4310036634 @default.
- W2034588313 hasRelatedWork W4385409030 @default.
- W2034588313 hasVolume "46" @default.