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- W2034594067 abstract "We have attempted to identify which parts of the brain react to ischemic attack using the four-vessel occlusion model in rats.We have monitored the expression of c-fos protein in the parietal cortex (R3 and T3) and in the olfactory tubercle (R4 and T4), regions which are supplied with blood by different arteries. The four-vessel occlusion was performed using the Pulsinelli's method and rats were divided into two groups: total ischemia (ligation of four blood vessels or coagulation of the vertebral artheries with bilateral ligation of carotid arteries - R group) and transient ischemic attack (ligation of four blood vessels or coagulation of the vertebral arteries with bilateral repeated ligation of carotid arteries - T group of rats, the so-called preconditioned group). Each of these groups had a control group.The results showed pronounced expression of c-fos neurons in T group of rats which can explain longer survival of neurons. We believe that this model can serve as a good starting point to developing new approaches to the therapy of brain ischemia." @default.
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- W2034594067 date "2007-01-01" @default.
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- W2034594067 title "C-fos protein expression in the parietal cortex and olfactory tubercle in the hypoxic rat brain" @default.
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- W2034594067 doi "https://doi.org/10.2298/mpns0704128p" @default.
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