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• W2034600017 endingPage "4474" @default.
• W2034600017 startingPage "4461" @default.
• W2034600017 abstract "ABSTRACT The minor capsid protein L2 of human papillomaviruses (HPVs) has multiple functions during the viral life cycle. Although L2 is required for effective invasion and morphogenesis, only a few cellular interaction partners are known so far. Using yeast two-hybrid screening, we identified the transcription factor TBX2 as a novel interaction partner of HPV type 16 (HPV16) L2. Coimmunoprecipitations and immunofluorescence analyses confirmed the L2-TBX2 interaction and revealed that L2 also interacts with TBX3, another member of the T-box family. Transcription of the early genes during HPV infection is under the control of an upstream enhancer and early promoter region, the long control region (LCR). In promoter-reporter gene assays, we observed that TBX2 and TBX3 repress transcription from the LCR and that this effect is enhanced by L2. Repression of the HPV LCR by TBX2/3 seems to be a conserved mechanism, as it was also observed with the LCRs of different HPV types. Finally, interaction of TBX2 with the LCR was detected by chromatin immunoprecipitation, and we found a strong colocalization of L2 and TBX2 in HPV16-positive cervical intraepithelial neoplasia (CIN) I-II tissue sections. These results suggest that TBX2/3 might play a role in the regulation of HPV gene expression during the viral life cycle." @default.
• W2034600017 created "2016-06-24" @default.
• W2034600017 creator A5014850676 @default.
• W2034600017 creator A5032180527 @default.
• W2034600017 creator A5032949870 @default.
• W2034600017 creator A5042830044 @default.
• W2034600017 creator A5052149703 @default.
• W2034600017 creator A5069801491 @default.
• W2034600017 creator A5073763574 @default.
• W2034600017 creator A5073991551 @default.
• W2034600017 creator A5085277126 @default.
• W2034600017 date "2013-04-15" @default.
• W2034600017 modified "2023-10-12" @default.
• W2034600017 title "The Transcription Factors TBX2 and TBX3 Interact with Human Papillomavirus 16 (HPV16) L2 and Repress the Long Control Region of HPVs" @default.
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• W2034600017 doi "https://doi.org/10.1128/jvi.01803-12" @default.

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