FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034602230> ?p ?o ?g. }

• W2034602230 endingPage "7720" @default.
• W2034602230 startingPage "7715" @default.
• W2034602230 abstract "Ellagic acid is a plant-derived polyphenol, possessing antioxidant, antiproliferative, and antiatherogenic properties. Whether this compound has estrogenic/antiestrogenic activity, however, remains largely unknown. To answer this question, we first investigated the ability of ellagic acid to influence the activity of the estrogen receptor subtypes ERα and ERβ in HeLa cells. Cells co-transfected with an estrogen response element (ERE)-driven luciferase (Luc) reporter gene and an ERα- or ERβ-expression vector were exposed to graded concentrations of ellagic acid. At low concentrations (10-7 to 10-9 M), this compound displayed a small but significant estrogenic activity via ERα, whereas it was a complete estrogen antagonist via ERβ. Further evaluation revealed that ellagic acid was a potent antiestrogen in MCF-7 breast cancer-derived cells, increasing, like the pure estrogen antagonist ICI182780, IGFBP-3 levels. Moreover, ellagic acid induced nodule mineralization in an osteoblastic cell line (KS483), an effect that was abolished by the estrogen antagonist. Endometrium-derived epithelial cells (Ishikawa) showed no response to the natural compound by using a cell viability assay (MTT). These findings suggest that ellagic acid may be a natural selective estrogen receptor modulator (SERM). Keywords: Ellagic acid; estrogen receptor alpha; estrogen receptor beta; selective estrogen receptor modulator; osteoblasts" @default.
• W2034602230 created "2016-06-24" @default.
• W2034602230 creator A5008723668 @default.
• W2034602230 creator A5025362288 @default.
• W2034602230 creator A5046164327 @default.
• W2034602230 creator A5054327912 @default.
• W2034602230 creator A5064230520 @default.
• W2034602230 creator A5081603647 @default.
• W2034602230 date "2005-09-01" @default.
• W2034602230 modified "2023-10-09" @default.
• W2034602230 title "Evaluation of Estrogenic/Antiestrogenic Activity of Ellagic Acid via the Estrogen Receptor Subtypes ERα and ERβ" @default.
• W2034602230 cites W1969191990 @default.
• W2034602230 cites W1970084894 @default.
• W2034602230 cites W1970531843 @default.
• W2034602230 cites W1972913677 @default.
• W2034602230 cites W1979616957 @default.
• W2034602230 cites W1980040001 @default.
• W2034602230 cites W1991645386 @default.
• W2034602230 cites W2011303018 @default.
• W2034602230 cites W2030205619 @default.
• W2034602230 cites W2033649912 @default.
• W2034602230 cites W2035059539 @default.
• W2034602230 cites W2036626471 @default.
• W2034602230 cites W2048863570 @default.
• W2034602230 cites W2049970571 @default.
• W2034602230 cites W2073944950 @default.
• W2034602230 cites W2076025678 @default.
• W2034602230 cites W2091099722 @default.
• W2034602230 cites W2098972988 @default.
• W2034602230 cites W2120254933 @default.
• W2034602230 cites W2128658043 @default.
• W2034602230 cites W2148574282 @default.
• W2034602230 cites W2161163254 @default.
• W2034602230 cites W2167550154 @default.
• W2034602230 cites W2187452737 @default.
• W2034602230 cites W2216094174 @default.
• W2034602230 cites W2314706738 @default.
• W2034602230 cites W4244187557 @default.
• W2034602230 doi "https://doi.org/10.1021/jf0510539" @default.
• W2034602230 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16190622" @default.
• W2034602230 hasPublicationYear "2005" @default.
• W2034602230 type Work @default.
• W2034602230 sameAs 2034602230 @default.
• W2034602230 citedByCount "86" @default.
• W2034602230 countsByYear W20346022302012 @default.
• W2034602230 countsByYear W20346022302013 @default.
• W2034602230 countsByYear W20346022302015 @default.
• W2034602230 countsByYear W20346022302016 @default.
• W2034602230 countsByYear W20346022302017 @default.
• W2034602230 countsByYear W20346022302018 @default.
• W2034602230 countsByYear W20346022302019 @default.
• W2034602230 countsByYear W20346022302020 @default.
• W2034602230 countsByYear W20346022302021 @default.
• W2034602230 countsByYear W20346022302022 @default.
• W2034602230 countsByYear W20346022302023 @default.
• W2034602230 crossrefType "journal-article" @default.
• W2034602230 hasAuthorship W2034602230A5008723668 @default.
• W2034602230 hasAuthorship W2034602230A5025362288 @default.
• W2034602230 hasAuthorship W2034602230A5046164327 @default.
• W2034602230 hasAuthorship W2034602230A5054327912 @default.
• W2034602230 hasAuthorship W2034602230A5064230520 @default.
• W2034602230 hasAuthorship W2034602230A5081603647 @default.
• W2034602230 hasConcept C121608353 @default.
• W2034602230 hasConcept C126322002 @default.
• W2034602230 hasConcept C134018914 @default.
• W2034602230 hasConcept C172313692 @default.
• W2034602230 hasConcept C185592680 @default.
• W2034602230 hasConcept C2777164284 @default.
• W2034602230 hasConcept C2777944059 @default.
• W2034602230 hasConcept C2778004101 @default.
• W2034602230 hasConcept C2781464872 @default.
• W2034602230 hasConcept C530470458 @default.
• W2034602230 hasConcept C55493867 @default.
• W2034602230 hasConcept C70899900 @default.
• W2034602230 hasConcept C71924100 @default.
• W2034602230 hasConcept C84606932 @default.
• W2034602230 hasConcept C86803240 @default.
• W2034602230 hasConcept C96307122 @default.
• W2034602230 hasConcept C98274493 @default.
• W2034602230 hasConceptScore W2034602230C121608353 @default.
• W2034602230 hasConceptScore W2034602230C126322002 @default.
• W2034602230 hasConceptScore W2034602230C134018914 @default.
• W2034602230 hasConceptScore W2034602230C172313692 @default.
• W2034602230 hasConceptScore W2034602230C185592680 @default.
• W2034602230 hasConceptScore W2034602230C2777164284 @default.
• W2034602230 hasConceptScore W2034602230C2777944059 @default.
• W2034602230 hasConceptScore W2034602230C2778004101 @default.
• W2034602230 hasConceptScore W2034602230C2781464872 @default.
• W2034602230 hasConceptScore W2034602230C530470458 @default.
• W2034602230 hasConceptScore W2034602230C55493867 @default.
• W2034602230 hasConceptScore W2034602230C70899900 @default.
• W2034602230 hasConceptScore W2034602230C71924100 @default.
• W2034602230 hasConceptScore W2034602230C84606932 @default.
• W2034602230 hasConceptScore W2034602230C86803240 @default.
• W2034602230 hasConceptScore W2034602230C96307122 @default.
• W2034602230 hasConceptScore W2034602230C98274493 @default.
• W2034602230 hasIssue "20" @default.
• W2034602230 hasLocation W20346022301 @default.

• next