Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034602267> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2034602267 endingPage "96" @default.
- W2034602267 startingPage "92" @default.
- W2034602267 abstract "Human fibroblast strains in vitro are markedly resistant to medium containing levels of 8-azahypoxanthine (AH) which are lethal to malignant cells. This difference depends on the presence of hypoxanthine in the fetal calf serum used to make standard tissue culture medium. Although malignant cells in culture possess approximately three times more effective hypoxanthine-guanine phosphoribosyl transferase (HGPRT) activity than normal cells, this does not account for the protective action of hypoxanthine in the latter. Rather, our data, together with that of others, suggest that hypoxanthine protects normal cells from AH by preventing its reaction with phosphoribosyl pyrophosphate via HGPRT. Whether this is the consequence of a qualitative difference between the HGPRT's of malignant and normal cells or a reflection of differential permeability to hypoxanthine requires further experimentation." @default.
- W2034602267 created "2016-06-24" @default.
- W2034602267 creator A5079175867 @default.
- W2034602267 creator A5079346046 @default.
- W2034602267 date "1971-11-01" @default.
- W2034602267 modified "2023-09-23" @default.
- W2034602267 title "Differential sensitivity of human normal and malignant cells to 8-azahypoxanthine in vitro" @default.
- W2034602267 cites W1568484857 @default.
- W2034602267 cites W1775749144 @default.
- W2034602267 cites W1991371734 @default.
- W2034602267 cites W1996362062 @default.
- W2034602267 cites W2005635581 @default.
- W2034602267 cites W2038352736 @default.
- W2034602267 cites W2051379695 @default.
- W2034602267 doi "https://doi.org/10.1016/0014-4827(71)90314-4" @default.
- W2034602267 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/5166378" @default.
- W2034602267 hasPublicationYear "1971" @default.
- W2034602267 type Work @default.
- W2034602267 sameAs 2034602267 @default.
- W2034602267 citedByCount "17" @default.
- W2034602267 countsByYear W20346022672017 @default.
- W2034602267 crossrefType "journal-article" @default.
- W2034602267 hasAuthorship W2034602267A5079175867 @default.
- W2034602267 hasAuthorship W2034602267A5079346046 @default.
- W2034602267 hasConcept C104317684 @default.
- W2034602267 hasConcept C121608353 @default.
- W2034602267 hasConcept C143065580 @default.
- W2034602267 hasConcept C153911025 @default.
- W2034602267 hasConcept C181199279 @default.
- W2034602267 hasConcept C202751555 @default.
- W2034602267 hasConcept C2777766392 @default.
- W2034602267 hasConcept C2778301229 @default.
- W2034602267 hasConcept C2780381497 @default.
- W2034602267 hasConcept C2781116151 @default.
- W2034602267 hasConcept C2909697302 @default.
- W2034602267 hasConcept C3019684167 @default.
- W2034602267 hasConcept C512185932 @default.
- W2034602267 hasConcept C54355233 @default.
- W2034602267 hasConcept C55493867 @default.
- W2034602267 hasConcept C78179603 @default.
- W2034602267 hasConcept C86803240 @default.
- W2034602267 hasConceptScore W2034602267C104317684 @default.
- W2034602267 hasConceptScore W2034602267C121608353 @default.
- W2034602267 hasConceptScore W2034602267C143065580 @default.
- W2034602267 hasConceptScore W2034602267C153911025 @default.
- W2034602267 hasConceptScore W2034602267C181199279 @default.
- W2034602267 hasConceptScore W2034602267C202751555 @default.
- W2034602267 hasConceptScore W2034602267C2777766392 @default.
- W2034602267 hasConceptScore W2034602267C2778301229 @default.
- W2034602267 hasConceptScore W2034602267C2780381497 @default.
- W2034602267 hasConceptScore W2034602267C2781116151 @default.
- W2034602267 hasConceptScore W2034602267C2909697302 @default.
- W2034602267 hasConceptScore W2034602267C3019684167 @default.
- W2034602267 hasConceptScore W2034602267C512185932 @default.
- W2034602267 hasConceptScore W2034602267C54355233 @default.
- W2034602267 hasConceptScore W2034602267C55493867 @default.
- W2034602267 hasConceptScore W2034602267C78179603 @default.
- W2034602267 hasConceptScore W2034602267C86803240 @default.
- W2034602267 hasIssue "1" @default.
- W2034602267 hasLocation W20346022671 @default.
- W2034602267 hasLocation W20346022672 @default.
- W2034602267 hasOpenAccess W2034602267 @default.
- W2034602267 hasPrimaryLocation W20346022671 @default.
- W2034602267 hasRelatedWork W2038104483 @default.
- W2034602267 hasRelatedWork W2045991316 @default.
- W2034602267 hasRelatedWork W2047567471 @default.
- W2034602267 hasRelatedWork W2055614050 @default.
- W2034602267 hasRelatedWork W2057817797 @default.
- W2034602267 hasRelatedWork W2060579897 @default.
- W2034602267 hasRelatedWork W2111583808 @default.
- W2034602267 hasRelatedWork W2416142347 @default.
- W2034602267 hasRelatedWork W2462948528 @default.
- W2034602267 hasRelatedWork W2084808266 @default.
- W2034602267 hasVolume "69" @default.
- W2034602267 isParatext "false" @default.
- W2034602267 isRetracted "false" @default.
- W2034602267 magId "2034602267" @default.
- W2034602267 workType "article" @default.