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• W2034602545 abstract "Abstract Human T-cell leukemia virus type-1 (HTLV-1) induces adult T-cell leukemia/lymphoma (ATL/L), a fatal lymphoproliferative disorder, and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), a chronic progressive disease of the central nervous system after a long period of latent infection. Although the mechanism of transformation and leukemogenesis is not fully elucidated, there is evidence to suggest that the viral oncoprotein Tax plays a crucial role in these processes through the regulation of several pathways including NF-κB and the cell cycle pathways. The observation that NF-κB, which is strongly induced by Tax, is indispensable for the maintenance of the malignant phenotype of HTLV-1 by regulating the expression of various genes involved in cell cycle regulation and inhibition of apoptosis provides a possible molecular target for these infected cells. To develop potential new therapeutic strategies for HTLV-1 infected cells, in this present study, we initially screened a battery of NF-κB and CDK inhibitors (total of 35 compounds) to examine their effects on the growth and survival of infected T-cell lines. Two drugs namely BMS-345541 and Purvalanol A exhibited higher levels of growth inhibition and apoptosis in infected cell as compared to uninfected cells. BMS-345541 inhibited IKKβ kinase activity from HTLV-1 infected cells with an IC 50 (the 50% of inhibitory concentration) value of 50 nM compared to 500 nM from control cells as measured by in vitro kinase assays. The effects of Purvalanol A were associated with suppression of CDK2/cyclin E complex activity as previously shown by us. Combination of both BMS-345541 and Purvalanol A showed a reduced level of HTLV-1 p19 Gag production in cell culture. The apparent apoptosis in these infected cells were associated with increased caspase-3 activity and PARP cleavage. The potent and selective apoptotic effects of these drugs suggest that both BMS-345541 and Purvalanol A, which target both NF-κB and CDK complex and the G1/S border, might be promising new agents in the treatment of these infected patients." @default.
• W2034602545 created "2016-06-24" @default.
• W2034602545 creator A5016700147 @default.
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• W2034602545 date "2008-06-10" @default.
• W2034602545 modified "2023-09-27" @default.
• W2034602545 title "Two specific drugs, BMS-345541 and purvalanol A induce apoptosis of HTLV-1 infected cells through inhibition of the NF-kappaB and cell cycle pathways" @default.
• W2034602545 cites W1524794013 @default.
• W2034602545 cites W1535684553 @default.
• W2034602545 cites W1581923494 @default.
• W2034602545 cites W1582302975 @default.
• W2034602545 cites W1607664081 @default.
• W2034602545 cites W1761867107 @default.
• W2034602545 cites W177084162 @default.
• W2034602545 cites W1914623489 @default.
• W2034602545 cites W1970174959 @default.
• W2034602545 cites W1976382352 @default.
• W2034602545 cites W1976983410 @default.
• W2034602545 cites W1978434703 @default.
• W2034602545 cites W1980746627 @default.
• W2034602545 cites W1983024867 @default.
• W2034602545 cites W1983486536 @default.
• W2034602545 cites W1986265440 @default.
• W2034602545 cites W1988502798 @default.
• W2034602545 cites W1989844987 @default.
• W2034602545 cites W1990957349 @default.
• W2034602545 cites W1994486114 @default.
• W2034602545 cites W1995670792 @default.
• W2034602545 cites W1999177172 @default.
• W2034602545 cites W1999693615 @default.
• W2034602545 cites W2002066494 @default.
• W2034602545 cites W2007456673 @default.
• W2034602545 cites W2010298858 @default.
• W2034602545 cites W2011588737 @default.
• W2034602545 cites W2018711510 @default.
• W2034602545 cites W2022142379 @default.
• W2034602545 cites W2028494050 @default.
• W2034602545 cites W2029311197 @default.
• W2034602545 cites W2036789689 @default.
• W2034602545 cites W2038928189 @default.
• W2034602545 cites W2046056065 @default.
• W2034602545 cites W2055182902 @default.
• W2034602545 cites W2056334059 @default.
• W2034602545 cites W2060110412 @default.
• W2034602545 cites W2062772646 @default.
• W2034602545 cites W2066916512 @default.
• W2034602545 cites W2076256408 @default.
• W2034602545 cites W2081145901 @default.
• W2034602545 cites W2085882015 @default.
• W2034602545 cites W20888715 @default.
• W2034602545 cites W2089225780 @default.
• W2034602545 cites W2090414390 @default.
• W2034602545 cites W2093973061 @default.
• W2034602545 cites W2094343556 @default.
• W2034602545 cites W2094831592 @default.
• W2034602545 cites W2097981550 @default.
• W2034602545 cites W2099566987 @default.
• W2034602545 cites W2100623645 @default.
• W2034602545 cites W2111642458 @default.
• W2034602545 cites W2113391491 @default.
• W2034602545 cites W2113898023 @default.
• W2034602545 cites W2116589659 @default.
• W2034602545 cites W2117408241 @default.
• W2034602545 cites W2118886727 @default.
• W2034602545 cites W2121619780 @default.
• W2034602545 cites W2122734862 @default.
• W2034602545 cites W2138059125 @default.
• W2034602545 cites W2144192014 @default.
• W2034602545 cites W2145338027 @default.
• W2034602545 cites W2145545337 @default.
• W2034602545 cites W2147370017 @default.
• W2034602545 cites W2149034242 @default.
• W2034602545 cites W2149138755 @default.
• W2034602545 cites W2152885495 @default.
• W2034602545 cites W2153516407 @default.
• W2034602545 cites W2154633327 @default.
• W2034602545 cites W2157155233 @default.
• W2034602545 cites W2162623315 @default.
• W2034602545 cites W2162744502 @default.
• W2034602545 cites W2164810650 @default.
• W2034602545 cites W2323754647 @default.
• W2034602545 cites W2427589873 @default.
• W2034602545 cites W245790771 @default.
• W2034602545 cites W2482952866 @default.
• W2034602545 cites W4246813004 @default.
• W2034602545 cites W4253961312 @default.
• W2034602545 doi "https://doi.org/10.1186/1742-6405-5-12" @default.
• W2034602545 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2483717" @default.
• W2034602545 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18544167" @default.
• W2034602545 hasPublicationYear "2008" @default.
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