Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034603185> ?p ?o ?g. }
- W2034603185 endingPage "310" @default.
- W2034603185 startingPage "296" @default.
- W2034603185 abstract "Kidney epithelia develop from the metanephric mesenchyme after receiving inductive signals from the ureteric bud and from the renal stroma. However, it is not clear how these signals induce the different types of epithelia that make up the nephron. To investigate inductive signaling, we have isolated clusters of epithelial progenitors from the metanephric mesenchyme, thereby separating them from the renal stroma. When the isolated progenitors were treated with the ureteric bud factor LIF, they expressed epithelial proteins (ZO-1, E-cadherin, laminin alpha(5)) and produced nephrons (36 glomeruli with 58 tubules), indicating that they are the target of inductive signaling from the ureteric bud, and that renal stroma is not absolutely required for epithelial development in vitro. In fact, stroma-depleted epithelial progenitors produced sevenfold more glomeruli than did intact metanephric mesenchyme (5 glomeruli, 127 tubules). Conversely, when epithelial progenitors were treated with both LIF and proteins secreted from a renal stromal cell line, glomerulogenesis was abolished but tubular epithelia were expanded (0 glomeruli, 47 tubules). Hence, by isolating epithelial progenitors from the metanephric mesenchyme, we show that they are targeted by factors from the ureteric bud and from the renal stroma, and that epithelial diversification is stimulated by the ureteric bud and limited by renal stroma." @default.
- W2034603185 created "2016-06-24" @default.
- W2034603185 creator A5016456840 @default.
- W2034603185 creator A5022111153 @default.
- W2034603185 creator A5036576511 @default.
- W2034603185 creator A5065076219 @default.
- W2034603185 creator A5081957060 @default.
- W2034603185 creator A5082925811 @default.
- W2034603185 date "2002-06-01" @default.
- W2034603185 modified "2023-10-14" @default.
- W2034603185 title "An Epithelial Precursor Is Regulated by the Ureteric Bud and by the Renal Stroma" @default.
- W2034603185 cites W119005760 @default.
- W2034603185 cites W1559573760 @default.
- W2034603185 cites W1596549154 @default.
- W2034603185 cites W1806182344 @default.
- W2034603185 cites W1857574091 @default.
- W2034603185 cites W1862598120 @default.
- W2034603185 cites W1873268238 @default.
- W2034603185 cites W1941707492 @default.
- W2034603185 cites W1942226155 @default.
- W2034603185 cites W1950995033 @default.
- W2034603185 cites W1956764277 @default.
- W2034603185 cites W1965785388 @default.
- W2034603185 cites W1969295674 @default.
- W2034603185 cites W1970547595 @default.
- W2034603185 cites W1971689970 @default.
- W2034603185 cites W1983228128 @default.
- W2034603185 cites W1987566228 @default.
- W2034603185 cites W1987964722 @default.
- W2034603185 cites W1988847595 @default.
- W2034603185 cites W1993974403 @default.
- W2034603185 cites W1995997868 @default.
- W2034603185 cites W2001475400 @default.
- W2034603185 cites W2011029364 @default.
- W2034603185 cites W2012361421 @default.
- W2034603185 cites W2013661702 @default.
- W2034603185 cites W2015565508 @default.
- W2034603185 cites W2015622740 @default.
- W2034603185 cites W2020542264 @default.
- W2034603185 cites W2021868064 @default.
- W2034603185 cites W2023321396 @default.
- W2034603185 cites W2029675195 @default.
- W2034603185 cites W2039309643 @default.
- W2034603185 cites W2049065981 @default.
- W2034603185 cites W2055069711 @default.
- W2034603185 cites W2055396768 @default.
- W2034603185 cites W2060041745 @default.
- W2034603185 cites W2061628657 @default.
- W2034603185 cites W2068728223 @default.
- W2034603185 cites W2076652674 @default.
- W2034603185 cites W2078091250 @default.
- W2034603185 cites W2080937698 @default.
- W2034603185 cites W2081285491 @default.
- W2034603185 cites W2083517562 @default.
- W2034603185 cites W2088424142 @default.
- W2034603185 cites W2088779677 @default.
- W2034603185 cites W2102636621 @default.
- W2034603185 cites W2117606428 @default.
- W2034603185 cites W2118272716 @default.
- W2034603185 cites W2118717572 @default.
- W2034603185 cites W2119657383 @default.
- W2034603185 cites W2122858554 @default.
- W2034603185 cites W2132963869 @default.
- W2034603185 cites W2133143415 @default.
- W2034603185 cites W2137333423 @default.
- W2034603185 cites W2142472665 @default.
- W2034603185 cites W2142830561 @default.
- W2034603185 cites W2143987989 @default.
- W2034603185 cites W2159098596 @default.
- W2034603185 cites W2161687343 @default.
- W2034603185 cites W2162885008 @default.
- W2034603185 cites W2163674890 @default.
- W2034603185 cites W2165123145 @default.
- W2034603185 cites W2186049400 @default.
- W2034603185 cites W2198246212 @default.
- W2034603185 cites W2322295216 @default.
- W2034603185 cites W2345807603 @default.
- W2034603185 cites W4236264229 @default.
- W2034603185 doi "https://doi.org/10.1006/dbio.2002.0646" @default.
- W2034603185 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12051817" @default.
- W2034603185 hasPublicationYear "2002" @default.
- W2034603185 type Work @default.
- W2034603185 sameAs 2034603185 @default.
- W2034603185 citedByCount "46" @default.
- W2034603185 countsByYear W20346031852012 @default.
- W2034603185 countsByYear W20346031852013 @default.
- W2034603185 countsByYear W20346031852014 @default.
- W2034603185 countsByYear W20346031852015 @default.
- W2034603185 countsByYear W20346031852016 @default.
- W2034603185 countsByYear W20346031852017 @default.
- W2034603185 countsByYear W20346031852018 @default.
- W2034603185 countsByYear W20346031852019 @default.
- W2034603185 countsByYear W20346031852020 @default.
- W2034603185 countsByYear W20346031852021 @default.
- W2034603185 countsByYear W20346031852023 @default.
- W2034603185 crossrefType "journal-article" @default.
- W2034603185 hasAuthorship W2034603185A5016456840 @default.
- W2034603185 hasAuthorship W2034603185A5022111153 @default.