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- W2034603430 abstract "[3H8]Leukotriene C4 was administered to germfree rats and to conventional rats having a bile duct cannula. Several radioactive metabolites were isolated. Two polar biliary metabolites from conventional rats were identified as N-acetyl-omega-carboxy-leukotriene E4 and N-acetyl-omega-hydroxy-leukotriene E4. A polar fecal metabolite from germfree rats was found to be N-acetyl-omega-carboxy-leukotriene E4. Chemical identities were established using UV spectroscopy and cochromatographies with authentic compounds in several HPLC systems. The fecal metabolite was further characterized by reductive desulfurization followed by gas-liquid-radiochromatography. The yield of the two biliary metabolites was 5% of the administered tritium after three hours and the yield of fecal N-acetyl-omega-carboxy-leukotriene E4 was 3.5% after three days." @default.
- W2034603430 created "2016-06-24" @default.
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- W2034603430 date "1988-04-01" @default.
- W2034603430 modified "2023-10-10" @default.
- W2034603430 title "In vitro formation of ω-oxidized metabolites of leukotriene C4 in the rat" @default.
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- W2034603430 doi "https://doi.org/10.1016/0090-6980(88)90025-1" @default.
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