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• W2034604614 endingPage "1895" @default.
• W2034604614 startingPage "1887" @default.
• W2034604614 abstract "The Japanese medaka fish Oryzias latipes has an XX/XY sex-determination system. The Y-linked sex-determination gene DMY is a duplicate of the autosomal gene DMRT1, which encodes a DM-domain-containing transcriptional factor. DMY appears to have originated recently within Oryzias, allowing a detailed evolutionary study of the initial steps that led to the new gene and new sex-determination system. Here I analyze the publicly available DMRT1 and DMY gene sequences of Oryzias species and report the following findings. First, the synonymous substitution rate in DMY is 1.73 times that in DMRT1, consistent with the male-driven evolution hypothesis. Second, the ratio of the rate of nonsynonymous nucleotide substitution (d(N)) to that of synonymous substitution (d(S)) is significantly higher in DMY than in DMRT1. Third, in DMRT1, the d(N)/d(S) ratio for the DM domain is lower than that for non-DM regions, as expected from the functional importance of the DM domain. But in DMY, the opposite is observed and the DM domain is likely under positive Darwinian selection. Fourth, only one characteristic amino acid distinguishes all DMY sequences from all DMRT1 sequences, suggesting that a single amino acid change may be largely responsible for the establishment of DMY as the male sex-determination gene in medaka fish." @default.
• W2034604614 created "2016-06-24" @default.
• W2034604614 creator A5082143549 @default.
• W2034604614 date "2004-04-01" @default.
• W2034604614 modified "2023-09-25" @default.
• W2034604614 title "Evolution of DMY, a Newly Emergent Male Sex-Determination Gene of Medaka Fish" @default.
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• W2034604614 doi "https://doi.org/10.1534/genetics.166.4.1887" @default.
• W2034604614 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1470821" @default.
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