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- W2034604992 abstract "We analyzed the role of P/Q-type calcium channels in sciatic nerve regeneration after lesion induced by chronic constriction injury (CCI) in heterozygous null mutant mice lacking the CaV2.1α1 subunit of these channels (Cacna1a+/−). Compared with wild type, Cacna1a+/− mice showed an initial reduction of the CCI-induced allodynia, indicating a reduced pain perception, but they also evidenced a lack of recovery over time, with atrophy of the injured hindpaw still present 3 months after CCI when wild-type mice fully recovered. In parallel, Cacna1a+/− mice exhibited an early onset of age-dependent loss of P/Q-type channels, which can be responsible for the lack of functional recovery. Moreover, Cacna1a+/− mice showed an early age-dependent reduction of muscular strength, as well as of Schwann cells proliferation and sciatic nerve remyelination. This study demonstrates the important role played by P/Q-type channels in recovery from nerve injury and has important implications for the knowledge of age-related processes." @default.
- W2034604992 created "2016-06-24" @default.
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- W2034604992 date "2015-01-01" @default.
- W2034604992 modified "2023-09-26" @default.
- W2034604992 title "Effects of age-related loss of P/Q-type calcium channels in a mice model of peripheral nerve injury" @default.
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- W2034604992 doi "https://doi.org/10.1016/j.neurobiolaging.2014.07.025" @default.
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