FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034605873> ?p ?o ?g. }

• W2034605873 endingPage "297" @default.
• W2034605873 startingPage "287" @default.
• W2034605873 abstract "Alzheimer's disease (AD) is characterized by disturbances of visuospatial cognition. Given that these impairments are closely related to metabolic and neuropathological changes, our study aimed to investigate the functional competency of brain regions in the visuospatial networks responsible for early clinical symptoms in AD using event-related functional magnetic resonance imaging (fMRI). Participants (13AD patients with mild symptoms and 13 age- and education-matched controls) performed an angle discrimination task with varying task demand. Using a novel approach that modeled the dependency of the blood oxygenation level-dependent (BOLD) signal on the subject's reaction time allowed us to investigate task demand-dependent signal changes between the groups. Both groups demonstrated overlapping neural networks engaged in angle discrimination, including the parieto-occipital and frontal regions. In several network regions, AD patients showed a significantly weaker and sometimes no BOLD signal due to increased task demand compared with controls, demonstrating failure to modulate the neural response to increased task demand. A general task demand-independent increase of activation in AD patients compared with controls was found in right middle temporal gyrus. This latter finding may indicate an attempt to compensate for dysfunctional areas in the dorsal visual pathway. These results confirm deficits in visuospatial abilities, which occur early in AD, and offer new insights into the neural mechanisms underlying this impairment." @default.
• W2034605873 created "2016-06-24" @default.
• W2034605873 creator A5018825962 @default.
• W2034605873 creator A5050932653 @default.
• W2034605873 creator A5057415951 @default.
• W2034605873 creator A5060153949 @default.
• W2034605873 creator A5068192515 @default.
• W2034605873 creator A5083928049 @default.
• W2034605873 creator A5087294774 @default.
• W2034605873 date "2008-09-01" @default.
• W2034605873 modified "2023-09-30" @default.
• W2034605873 title "Failure to modulate neural response to increased task demand in mild Alzheimer's disease: fMRI study of visuospatial processing" @default.
• W2034605873 cites W1821885973 @default.
• W2034605873 cites W1847168837 @default.
• W2034605873 cites W1967790471 @default.
• W2034605873 cites W1976171769 @default.
• W2034605873 cites W1986966802 @default.
• W2034605873 cites W1991952617 @default.
• W2034605873 cites W1999824728 @default.
• W2034605873 cites W2000555003 @default.
• W2034605873 cites W2002660165 @default.
• W2034605873 cites W2018418098 @default.
• W2034605873 cites W2021930389 @default.
• W2034605873 cites W2024612094 @default.
• W2034605873 cites W2028434676 @default.
• W2034605873 cites W2040490831 @default.
• W2034605873 cites W2044474088 @default.
• W2034605873 cites W2044634376 @default.
• W2034605873 cites W2046303156 @default.
• W2034605873 cites W2050717100 @default.
• W2034605873 cites W2053127376 @default.
• W2034605873 cites W2060629467 @default.
• W2034605873 cites W2070490664 @default.
• W2034605873 cites W2079560417 @default.
• W2034605873 cites W2082657804 @default.
• W2034605873 cites W2085684318 @default.
• W2034605873 cites W2087492248 @default.
• W2034605873 cites W2091532520 @default.
• W2034605873 cites W2095827013 @default.
• W2034605873 cites W2100879297 @default.
• W2034605873 cites W2102099746 @default.
• W2034605873 cites W2105118669 @default.
• W2034605873 cites W2113406852 @default.
• W2034605873 cites W2114104729 @default.
• W2034605873 cites W2115333483 @default.
• W2034605873 cites W2115462438 @default.
• W2034605873 cites W2121544226 @default.
• W2034605873 cites W2123171640 @default.
• W2034605873 cites W2143850783 @default.
• W2034605873 cites W2144814157 @default.
• W2034605873 cites W2152060070 @default.
• W2034605873 cites W2161547767 @default.
• W2034605873 cites W2162298355 @default.
• W2034605873 cites W2167670126 @default.
• W2034605873 cites W2170117095 @default.
• W2034605873 cites W2276200794 @default.
• W2034605873 cites W50072833 @default.
• W2034605873 doi "https://doi.org/10.1016/j.nbd.2008.04.013" @default.
• W2034605873 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18619845" @default.
• W2034605873 hasPublicationYear "2008" @default.
• W2034605873 type Work @default.
• W2034605873 sameAs 2034605873 @default.
• W2034605873 citedByCount "28" @default.
• W2034605873 countsByYear W20346058732012 @default.
• W2034605873 countsByYear W20346058732013 @default.
• W2034605873 countsByYear W20346058732014 @default.
• W2034605873 countsByYear W20346058732016 @default.
• W2034605873 countsByYear W20346058732017 @default.
• W2034605873 countsByYear W20346058732019 @default.
• W2034605873 countsByYear W20346058732020 @default.
• W2034605873 countsByYear W20346058732021 @default.
• W2034605873 countsByYear W20346058732022 @default.
• W2034605873 countsByYear W20346058732023 @default.
• W2034605873 crossrefType "journal-article" @default.
• W2034605873 hasAuthorship W2034605873A5018825962 @default.
• W2034605873 hasAuthorship W2034605873A5050932653 @default.
• W2034605873 hasAuthorship W2034605873A5057415951 @default.
• W2034605873 hasAuthorship W2034605873A5060153949 @default.
• W2034605873 hasAuthorship W2034605873A5068192515 @default.
• W2034605873 hasAuthorship W2034605873A5083928049 @default.
• W2034605873 hasAuthorship W2034605873A5087294774 @default.
• W2034605873 hasConcept C118552586 @default.
• W2034605873 hasConcept C15744967 @default.
• W2034605873 hasConcept C162324750 @default.
• W2034605873 hasConcept C169760540 @default.
• W2034605873 hasConcept C169900460 @default.
• W2034605873 hasConcept C187736073 @default.
• W2034605873 hasConcept C27502469 @default.
• W2034605873 hasConcept C2779226451 @default.
• W2034605873 hasConcept C2779991468 @default.
• W2034605873 hasConcept C2780451532 @default.
• W2034605873 hasConcept C548259974 @default.
• W2034605873 hasConcept C71924100 @default.
• W2034605873 hasConceptScore W2034605873C118552586 @default.
• W2034605873 hasConceptScore W2034605873C15744967 @default.
• W2034605873 hasConceptScore W2034605873C162324750 @default.
• W2034605873 hasConceptScore W2034605873C169760540 @default.
• W2034605873 hasConceptScore W2034605873C169900460 @default.

• next