Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034606094> ?p ?o ?g. }
- W2034606094 endingPage "662" @default.
- W2034606094 startingPage "653" @default.
- W2034606094 abstract "Fluoxetine and its circulating metabolite norfluoxetine comprise a complex multiple-inhibitor system that causes reversible or time-dependent inhibition of the cytochrome P450 (CYP) family members CYP2D6, CYP3A4, and CYP2C19 in vitro. Although significant inhibition of all three enzymes in vivo was predicted, the areas under the concentration–time curve (AUCs) for midazolam and lovastatin were unaffected by 2-week dosing of fluoxetine, whereas the AUCs of dextromethorphan and omeprazole were increased by 27- and 7.1-fold, respectively. This observed discrepancy between in vitro risk assessment and in vivo drug–drug interaction (DDI) profile was rationalized by time-varying dynamic pharmacokinetic models that incorporated circulating concentrations of fluoxetine and norfluoxetine enantiomers, mutual inhibitor–inhibitor interactions, and CYP3A4 induction. The dynamic models predicted all DDIs with less than twofold error. This study demonstrates that complex DDIs that involve multiple mechanisms, pathways, and inhibitors with their metabolites can be predicted and rationalized via characterization of all the inhibitory species in vitro. Clinical Pharmacology & Therapeutics (2014); 95 6, 653–662. doi:10.1038/clpt.2014.50" @default.
- W2034606094 created "2016-06-24" @default.
- W2034606094 creator A5033935259 @default.
- W2034606094 creator A5036636635 @default.
- W2034606094 creator A5053520211 @default.
- W2034606094 creator A5068941997 @default.
- W2034606094 creator A5072154392 @default.
- W2034606094 creator A5077577603 @default.
- W2034606094 date "2014-02-25" @default.
- W2034606094 modified "2023-10-12" @default.
- W2034606094 title "Fluoxetine- and Norfluoxetine-Mediated Complex Drug–Drug Interactions: In Vitro to In Vivo Correlation of Effects on CYP2D6, CYP2C19, and CYP3A4" @default.
- W2034606094 cites W1964525922 @default.
- W2034606094 cites W1972174137 @default.
- W2034606094 cites W1979177892 @default.
- W2034606094 cites W1980580492 @default.
- W2034606094 cites W1981109961 @default.
- W2034606094 cites W1981566729 @default.
- W2034606094 cites W1985034927 @default.
- W2034606094 cites W2004794401 @default.
- W2034606094 cites W2007801356 @default.
- W2034606094 cites W2010944453 @default.
- W2034606094 cites W2022420472 @default.
- W2034606094 cites W2028342467 @default.
- W2034606094 cites W2028912886 @default.
- W2034606094 cites W2035787557 @default.
- W2034606094 cites W2044002533 @default.
- W2034606094 cites W2052321118 @default.
- W2034606094 cites W2054023900 @default.
- W2034606094 cites W2057657052 @default.
- W2034606094 cites W2070325710 @default.
- W2034606094 cites W2072044044 @default.
- W2034606094 cites W2079760663 @default.
- W2034606094 cites W2085817407 @default.
- W2034606094 cites W2100135272 @default.
- W2034606094 cites W2105005467 @default.
- W2034606094 cites W2106377498 @default.
- W2034606094 cites W2110924339 @default.
- W2034606094 cites W2113533305 @default.
- W2034606094 cites W2117809065 @default.
- W2034606094 cites W2122651109 @default.
- W2034606094 cites W2129701778 @default.
- W2034606094 cites W2129998904 @default.
- W2034606094 cites W2145804143 @default.
- W2034606094 cites W2157227177 @default.
- W2034606094 cites W2161526651 @default.
- W2034606094 cites W2164113828 @default.
- W2034606094 cites W2166861655 @default.
- W2034606094 cites W2168223091 @default.
- W2034606094 cites W5814429 @default.
- W2034606094 doi "https://doi.org/10.1038/clpt.2014.50" @default.
- W2034606094 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4029899" @default.
- W2034606094 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24569517" @default.
- W2034606094 hasPublicationYear "2014" @default.
- W2034606094 type Work @default.
- W2034606094 sameAs 2034606094 @default.
- W2034606094 citedByCount "67" @default.
- W2034606094 countsByYear W20346060942014 @default.
- W2034606094 countsByYear W20346060942015 @default.
- W2034606094 countsByYear W20346060942016 @default.
- W2034606094 countsByYear W20346060942017 @default.
- W2034606094 countsByYear W20346060942018 @default.
- W2034606094 countsByYear W20346060942019 @default.
- W2034606094 countsByYear W20346060942020 @default.
- W2034606094 countsByYear W20346060942021 @default.
- W2034606094 countsByYear W20346060942022 @default.
- W2034606094 countsByYear W20346060942023 @default.
- W2034606094 crossrefType "journal-article" @default.
- W2034606094 hasAuthorship W2034606094A5033935259 @default.
- W2034606094 hasAuthorship W2034606094A5036636635 @default.
- W2034606094 hasAuthorship W2034606094A5053520211 @default.
- W2034606094 hasAuthorship W2034606094A5068941997 @default.
- W2034606094 hasAuthorship W2034606094A5072154392 @default.
- W2034606094 hasAuthorship W2034606094A5077577603 @default.
- W2034606094 hasBestOaLocation W20346060942 @default.
- W2034606094 hasConcept C109650736 @default.
- W2034606094 hasConcept C112705442 @default.
- W2034606094 hasConcept C140840227 @default.
- W2034606094 hasConcept C149151106 @default.
- W2034606094 hasConcept C150903083 @default.
- W2034606094 hasConcept C170493617 @default.
- W2034606094 hasConcept C181199279 @default.
- W2034606094 hasConcept C185592680 @default.
- W2034606094 hasConcept C202751555 @default.
- W2034606094 hasConcept C207001950 @default.
- W2034606094 hasConcept C2775864247 @default.
- W2034606094 hasConcept C2776134451 @default.
- W2034606094 hasConcept C2777477808 @default.
- W2034606094 hasConcept C2777498785 @default.
- W2034606094 hasConcept C2780035454 @default.
- W2034606094 hasConcept C2781245242 @default.
- W2034606094 hasConcept C33664856 @default.
- W2034606094 hasConcept C526171541 @default.
- W2034606094 hasConcept C55493867 @default.
- W2034606094 hasConcept C71924100 @default.
- W2034606094 hasConcept C86803240 @default.
- W2034606094 hasConcept C97320921 @default.
- W2034606094 hasConcept C98274493 @default.
- W2034606094 hasConceptScore W2034606094C109650736 @default.