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- W2034606149 abstract "Labeled β-muricholic acid was obtained from germfree rats given [24-14C]-chenodeoxycholic acid. It was crystallized with the same unlabeled bile acid extracted from germfree rat pooled biles. Five patients fitted with a T-tube after cholecystectomy were given orally 100 mg of the bile acid. Metabolites of β-muricholic acid in bile, urine and feces were studied. Glyco- and tauro-β-muricholic acid were the only metabolites detected in bile. The urinary bile acid pattern was complex and included free, glyco- and sulfoconjugated β-muricholic acid, but no glucuronide was observed. Analysis of fecal bile acid showed very few metabolites: the 3β-epimer was identified; the 6β- and 7β-hydroxyls were apparently not transformed by human intestinal microflora." @default.
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- W2034606149 date "1985-05-01" @default.
- W2034606149 modified "2023-10-13" @default.
- W2034606149 title "Metabolism of β-muricholic acid in man" @default.
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- W2034606149 doi "https://doi.org/10.1016/0039-128x(85)90006-6" @default.
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