Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034606779> ?p ?o ?g. }
- W2034606779 endingPage "79" @default.
- W2034606779 startingPage "70" @default.
- W2034606779 abstract "The capsids of mature retroviruses perform the essential function of organizing the viral genome for efficient replication. These capsids are modeled as fullerene structures composed of closed hexameric arrays of the viral CA protein, but a high-resolution structure of the lattice has remained elusive. A three-dimensional map of two-dimensional crystals of the R18L mutant of HIV-1 CA was derived by electron cryocrystallography. The docking of high-resolution domain structures into the map yielded the first unambiguous model for full-length HIV-1 CA. Three important protein-protein assembly interfaces are required for capsid formation. Each CA hexamer is composed of an inner ring of six N-terminal domains and an outer ring of C-terminal domains that form dimeric linkers connecting neighboring hexamers. Interactions between the two domains of CA further stabilize the hexamer and provide a structural explanation for the mechanism of action of known HIV-1 assembly inhibitors." @default.
- W2034606779 created "2016-06-24" @default.
- W2034606779 creator A5018020732 @default.
- W2034606779 creator A5039922484 @default.
- W2034606779 creator A5070557615 @default.
- W2034606779 date "2007-10-01" @default.
- W2034606779 modified "2023-10-11" @default.
- W2034606779 title "Structure of Full-Length HIV-1 CA: A Model for the Mature Capsid Lattice" @default.
- W2034606779 cites W1507707072 @default.
- W2034606779 cites W1816747902 @default.
- W2034606779 cites W1965581896 @default.
- W2034606779 cites W1968718594 @default.
- W2034606779 cites W1969392841 @default.
- W2034606779 cites W1972147363 @default.
- W2034606779 cites W1972860653 @default.
- W2034606779 cites W1986015062 @default.
- W2034606779 cites W1991485090 @default.
- W2034606779 cites W1992405607 @default.
- W2034606779 cites W1994475804 @default.
- W2034606779 cites W1996204565 @default.
- W2034606779 cites W2007107624 @default.
- W2034606779 cites W2008394972 @default.
- W2034606779 cites W2013652077 @default.
- W2034606779 cites W2015090760 @default.
- W2034606779 cites W2016367858 @default.
- W2034606779 cites W2018974829 @default.
- W2034606779 cites W2035350295 @default.
- W2034606779 cites W2036372832 @default.
- W2034606779 cites W2037074791 @default.
- W2034606779 cites W2042516964 @default.
- W2034606779 cites W2052167675 @default.
- W2034606779 cites W2055643881 @default.
- W2034606779 cites W2056139158 @default.
- W2034606779 cites W2061714407 @default.
- W2034606779 cites W2062334646 @default.
- W2034606779 cites W2066053818 @default.
- W2034606779 cites W2071827167 @default.
- W2034606779 cites W2073178398 @default.
- W2034606779 cites W2076449818 @default.
- W2034606779 cites W2076467539 @default.
- W2034606779 cites W2076965602 @default.
- W2034606779 cites W2078739781 @default.
- W2034606779 cites W2086639577 @default.
- W2034606779 cites W2093650342 @default.
- W2034606779 cites W2110810808 @default.
- W2034606779 cites W2117178888 @default.
- W2034606779 cites W2121753315 @default.
- W2034606779 cites W2132483341 @default.
- W2034606779 cites W2135035609 @default.
- W2034606779 cites W2137919235 @default.
- W2034606779 cites W2138792611 @default.
- W2034606779 cites W2150469985 @default.
- W2034606779 cites W2156696460 @default.
- W2034606779 cites W2159504933 @default.
- W2034606779 cites W2161323000 @default.
- W2034606779 cites W2161840329 @default.
- W2034606779 cites W2168482038 @default.
- W2034606779 cites W2318822509 @default.
- W2034606779 doi "https://doi.org/10.1016/j.cell.2007.08.018" @default.
- W2034606779 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17923088" @default.
- W2034606779 hasPublicationYear "2007" @default.
- W2034606779 type Work @default.
- W2034606779 sameAs 2034606779 @default.
- W2034606779 citedByCount "300" @default.
- W2034606779 countsByYear W20346067792012 @default.
- W2034606779 countsByYear W20346067792013 @default.
- W2034606779 countsByYear W20346067792014 @default.
- W2034606779 countsByYear W20346067792015 @default.
- W2034606779 countsByYear W20346067792016 @default.
- W2034606779 countsByYear W20346067792017 @default.
- W2034606779 countsByYear W20346067792018 @default.
- W2034606779 countsByYear W20346067792019 @default.
- W2034606779 countsByYear W20346067792020 @default.
- W2034606779 countsByYear W20346067792021 @default.
- W2034606779 countsByYear W20346067792022 @default.
- W2034606779 countsByYear W20346067792023 @default.
- W2034606779 crossrefType "journal-article" @default.
- W2034606779 hasAuthorship W2034606779A5018020732 @default.
- W2034606779 hasAuthorship W2034606779A5039922484 @default.
- W2034606779 hasAuthorship W2034606779A5070557615 @default.
- W2034606779 hasBestOaLocation W20346067791 @default.
- W2034606779 hasConcept C104317684 @default.
- W2034606779 hasConcept C12554922 @default.
- W2034606779 hasConcept C143065580 @default.
- W2034606779 hasConcept C153911025 @default.
- W2034606779 hasConcept C159047783 @default.
- W2034606779 hasConcept C159110408 @default.
- W2034606779 hasConcept C185592680 @default.
- W2034606779 hasConcept C189754071 @default.
- W2034606779 hasConcept C202878990 @default.
- W2034606779 hasConcept C2522874641 @default.
- W2034606779 hasConcept C2780879997 @default.
- W2034606779 hasConcept C41685203 @default.
- W2034606779 hasConcept C47701112 @default.
- W2034606779 hasConcept C54355233 @default.
- W2034606779 hasConcept C55493867 @default.
- W2034606779 hasConcept C71924100 @default.
- W2034606779 hasConcept C8010536 @default.