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- W2034607369 abstract "Various abnormalities have been described in B cells from patients with systemic autoimmune diseases such as systemic lupus erythematosus (SLE) and lupus-prone mice. Many of the abnormalities do not appear to be connected with the pathogenesis of the disease. However, various animal models developing lupus-like disease including both spontaneous mutants such as (NZB × NZW)F1 and MRL/lpr and mice generated by transgenic or knockout technology such as Bim-deficient and CD40L-transgenic mice show defect in apoptosis of mature B cells induced by ligation of the B cell antigen receptor (BCR). BCR-mediated apoptosis appears to be involved in deletion of self-reactive B cells. Thus, defect in BCR-mediated apoptosis is a widely observed B cell abnormality in lupus-prone mice and may play a role in the pathogenesis of systemic autoimmune diseases by abrogating deletion of self-reactive B cells." @default.
- W2034607369 created "2016-06-24" @default.
- W2034607369 creator A5078122217 @default.
- W2034607369 date "2005-01-01" @default.
- W2034607369 modified "2023-09-23" @default.
- W2034607369 title "B cell abnormality and autoimmune disorders" @default.
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- W2034607369 doi "https://doi.org/10.1080/08916930500123959" @default.
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