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- W2034607763 endingPage "597" @default.
- W2034607763 startingPage "592" @default.
- W2034607763 abstract "The phosphoinositide 3-kinase signaling pathway regulates a range of T lymphocyte cellular functions including growth, proliferation, cytokine secretion and survival. Aberrant regulation of phosphoinositide 3-kinase-dependent signaling in T lymphocytes has been implicated in inflammatory and autoimmune diseases. In common with much of the immune system, several mechanisms exist to ensure the pathway is tightly regulated to elicit appropriate responses. One level of control involves the Src homology 2 domain-containing inositol-5-phosphatase-1 (SHIP-1) that modulates phosphoinositide 3-kinase signaling by degrading the key signaling lipid PI(3,4,5)P3 to PI(3,4)P2, but also serves as a key scaffolding molecule in the formation of multi-protein complexes. Here we discuss the role of SHIP-1 in regulating T lymphocyte and immune function, as well as its potential as a therapeutic target." @default.
- W2034607763 created "2016-06-24" @default.
- W2034607763 creator A5011008775 @default.
- W2034607763 creator A5029868837 @default.
- W2034607763 creator A5033414427 @default.
- W2034607763 date "2010-03-01" @default.
- W2034607763 modified "2023-10-04" @default.
- W2034607763 title "Fine tuning T lymphocytes: A role for the lipid phosphatase SHIP-1" @default.
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- W2034607763 doi "https://doi.org/10.1016/j.bbapap.2009.09.019" @default.
- W2034607763 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19782768" @default.
- W2034607763 hasPublicationYear "2010" @default.
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