FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034608385> ?p ?o ?g. }

• W2034608385 endingPage "12" @default.
• W2034608385 startingPage "1" @default.
• W2034608385 abstract "The effects of ascorbic acid and hydrocortisone on activity of prolyl hydroxylase in fibroblasts from keloid and normal human dermis were investigated and compared to the effects of these agents on collagen synthesis. Prolyl hydroxylase activity in normal fibroblasts grown to confluency in 1.5 microM hydrocortisone was approximately half that of cells grown without the steroid. The concentration of hydrocortisone effective in reducing enzyme activity was the same as that for reducing the rate of collagen synthesis; a half-maximal effect on both parameters was achieved at 10(-7) M. Hydrocortisone lowered enzyme activity through most of the culture cycle. Fibroblasts derived from keloids were significantly less subject to hydrocortisone-mediated reduction of prolyl hydroxylase activity and rate of collagen synthesis. This difference between keloid and normal cells was dependent on the simultaneous presence of ascorbic acid and hydrocortisone. These data suggest that the defect in wound healing that results in keloid formation is associated with a change in a regulatory mechanism that controls the rate of collagen synthesis and is sensitive to physiological levels of hydrocortisone. Continuous culture of fibroblasts in medium supplemented with ascorbic acid also lowered prolyl hydroxylase activity. Unlike the effect of hydrocortisone, growth in ascorbate increased the rate of collagen synthesis and affected keloid and normal strains equally." @default.
• W2034608385 created "2016-06-24" @default.
• W2034608385 creator A5000716106 @default.
• W2034608385 creator A5024339103 @default.
• W2034608385 creator A5081122792 @default.
• W2034608385 date "1983-01-01" @default.
• W2034608385 modified "2023-10-04" @default.
• W2034608385 title "Variation in Prolyl Hydroxylase Activity of Keloid-Derived and Normal Human Fibroblasts in Response to Hydrocortisone and Ascorbic Acid" @default.
• W2034608385 cites W1520294010 @default.
• W2034608385 cites W1604541303 @default.
• W2034608385 cites W184029216 @default.
• W2034608385 cites W1970745644 @default.
• W2034608385 cites W1973381763 @default.
• W2034608385 cites W1977748818 @default.
• W2034608385 cites W1984788741 @default.
• W2034608385 cites W1986290908 @default.
• W2034608385 cites W1999329438 @default.
• W2034608385 cites W2016785566 @default.
• W2034608385 cites W2026954329 @default.
• W2034608385 cites W2028220484 @default.
• W2034608385 cites W2034905888 @default.
• W2034608385 cites W2046079118 @default.
• W2034608385 cites W2059906604 @default.
• W2034608385 cites W2062510144 @default.
• W2034608385 cites W2064481190 @default.
• W2034608385 cites W2067227865 @default.
• W2034608385 cites W2070945594 @default.
• W2034608385 cites W207596769 @default.
• W2034608385 cites W2077726017 @default.
• W2034608385 cites W2078516186 @default.
• W2034608385 cites W2151860884 @default.
• W2034608385 cites W2178696951 @default.
• W2034608385 cites W2322126443 @default.
• W2034608385 cites W2410817480 @default.
• W2034608385 cites W2413322683 @default.
• W2034608385 cites W2479047683 @default.
• W2034608385 doi "https://doi.org/10.1016/s0174-173x(83)80045-4" @default.
• W2034608385 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6301749" @default.
• W2034608385 hasPublicationYear "1983" @default.
• W2034608385 type Work @default.
• W2034608385 sameAs 2034608385 @default.
• W2034608385 citedByCount "24" @default.
• W2034608385 countsByYear W20346083852015 @default.
• W2034608385 countsByYear W20346083852017 @default.
• W2034608385 crossrefType "journal-article" @default.
• W2034608385 hasAuthorship W2034608385A5000716106 @default.
• W2034608385 hasAuthorship W2034608385A5024339103 @default.
• W2034608385 hasAuthorship W2034608385A5081122792 @default.
• W2034608385 hasConcept C126322002 @default.
• W2034608385 hasConcept C134018914 @default.
• W2034608385 hasConcept C16005928 @default.
• W2034608385 hasConcept C181199279 @default.
• W2034608385 hasConcept C185592680 @default.
• W2034608385 hasConcept C202751555 @default.
• W2034608385 hasConcept C2777459323 @default.
• W2034608385 hasConcept C2777538232 @default.
• W2034608385 hasConcept C2778709874 @default.
• W2034608385 hasConcept C2780381497 @default.
• W2034608385 hasConcept C2986274086 @default.
• W2034608385 hasConcept C31903555 @default.
• W2034608385 hasConcept C54355233 @default.
• W2034608385 hasConcept C55493867 @default.
• W2034608385 hasConcept C71924100 @default.
• W2034608385 hasConcept C86803240 @default.
• W2034608385 hasConceptScore W2034608385C126322002 @default.
• W2034608385 hasConceptScore W2034608385C134018914 @default.
• W2034608385 hasConceptScore W2034608385C16005928 @default.
• W2034608385 hasConceptScore W2034608385C181199279 @default.
• W2034608385 hasConceptScore W2034608385C185592680 @default.
• W2034608385 hasConceptScore W2034608385C202751555 @default.
• W2034608385 hasConceptScore W2034608385C2777459323 @default.
• W2034608385 hasConceptScore W2034608385C2777538232 @default.
• W2034608385 hasConceptScore W2034608385C2778709874 @default.
• W2034608385 hasConceptScore W2034608385C2780381497 @default.
• W2034608385 hasConceptScore W2034608385C2986274086 @default.
• W2034608385 hasConceptScore W2034608385C31903555 @default.
• W2034608385 hasConceptScore W2034608385C54355233 @default.
• W2034608385 hasConceptScore W2034608385C55493867 @default.
• W2034608385 hasConceptScore W2034608385C71924100 @default.
• W2034608385 hasConceptScore W2034608385C86803240 @default.
• W2034608385 hasIssue "1" @default.
• W2034608385 hasLocation W20346083851 @default.
• W2034608385 hasLocation W20346083852 @default.
• W2034608385 hasOpenAccess W2034608385 @default.
• W2034608385 hasPrimaryLocation W20346083851 @default.
• W2034608385 hasRelatedWork W1966798818 @default.
• W2034608385 hasRelatedWork W2006670632 @default.
• W2034608385 hasRelatedWork W2034608385 @default.
• W2034608385 hasRelatedWork W2081402487 @default.
• W2034608385 hasRelatedWork W2084703504 @default.
• W2034608385 hasRelatedWork W2137351911 @default.
• W2034608385 hasRelatedWork W2147256274 @default.
• W2034608385 hasRelatedWork W2156430177 @default.
• W2034608385 hasRelatedWork W2886134620 @default.
• W2034608385 hasRelatedWork W4241864131 @default.
• W2034608385 hasVolume "3" @default.
• W2034608385 isParatext "false" @default.
• W2034608385 isRetracted "false" @default.

• next