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• W2034608884 abstract "We investigated the effects of a polymorphic PvuII site in the gene for lecithin:cholesterol acyltransferase (LCAT) on serum high density lipoprotein cholesterol (HDL-C) and apolipoprotein A-I (apo A-I) concentrations in a population of 750 pedigreed baboons. We also tested for genotype by diet interactions using data on HDL-C and apo A-I concentrations on two diets (chow and high-cholesterol, saturated fat). A significant (P < 0.001) association between the LCAT genotypes and HDL-C levels was observed. On both diets, animals homozygous for the less common allele had HDL-C levels that averaged 18-19% lower than animals homozygous for the more common allele. HDL-C levels of the heterozygotes were intermediate. The LCAT RFLP accounted for approximately 5% of the variation in HDL-C levels on the two diets. We observed no strong evidence for an LCAT genotype by diet interaction effect." @default.
• W2034608884 created "2016-06-24" @default.
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• W2034608884 date "1993-01-01" @default.
• W2034608884 modified "2023-10-16" @default.
• W2034608884 title "A DNA polymorphism for lecithin: cholesterol acyltransferase (LCAT) is associated with high density lipoprotein cholesterol concentrations in baboons" @default.
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• W2034608884 doi "https://doi.org/10.1016/0021-9150(93)90125-e" @default.
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