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- W2034608909 abstract "Monoclonal antibodies penetrate bulky tumors poorly after intravenous administration, in part because of specific binding to the target antigen. Experiments presented here demonstrate an analogous phenomenon in micrometastases; poor antibody penetration, attributable to a binding-site barrier phenomenon, can be seen in guinea pig micrometastases as small as 300 microns in diameter. Increasing the dose of antibody can partially overcome this limitation, but at a cost in specificity." @default.
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- W2034608909 date "1995-09-12" @default.
- W2034608909 modified "2023-10-01" @default.
- W2034608909 title "Targeting cancer micrometastases with monoclonal antibodies: a binding-site barrier." @default.
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- W2034608909 doi "https://doi.org/10.1073/pnas.92.19.8999" @default.
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