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• W2034609232 endingPage "150" @default.
• W2034609232 startingPage "135" @default.
• W2034609232 abstract "1. Receptor-mediated modulation of the delayed outward potassium current (IK) was investigated in guinea-pig single ventricular cells by using whole-cell voltage clamp and intracellular dialysis. 2. Isoprenaline increased IK in a dose-dependent manner with a half-maximum dose of 1.8 X 10(-8) M. Isoprenaline (10(-6) M) maximally increased IK by a factor of 2.85. This effect did not depend on the concentration of intracellular Ca2+ [( Ca2+]i). 3. External application of 10(-5) M-forskolin and internal application of 5 X 10(-5) M-cyclic AMP or 5 X 10(-6) M of the catalytic subunit of cyclic AMP-dependent protein kinase (PKA) also increased IK about 3-fold. The effect of isoprenaline on IK was masked by previous application of cyclic AMP. 4. All the above phosphorylating agents increased the amplitude of IK without a significant change in the current kinetics. 5. In the presence of 10(-5) M-forskolin, an additional application of 10(-8) M-12-O-tetradecanoylphorbol-13-acetate, an activator of protein kinase C (PKC), produced a further increase in IK, suggesting that the active sites of PKA and PKC on the IK channel are different. 6. Acetylcholine (10(-6) M) suppressed IK when the current was previously enhanced by 2 X 10(-8) M-isoprenaline, but had little effect in the absence of isoprenaline. 7. We conclude that beta-adrenergic modulation of IK is mediated by cyclic AMP-dependent phosphorylation but not by an increase in [Ca2+]i, that PKA and PKC enhance IK independently, and that acetylcholine antagonizes beta-adrenergic stimulation of IK most probably by inhibiting adenylate cyclase." @default.
• W2034609232 created "2016-06-24" @default.
• W2034609232 creator A5035497917 @default.
• W2034609232 creator A5086725439 @default.
• W2034609232 date "1990-02-01" @default.
• W2034609232 modified "2023-09-24" @default.
• W2034609232 title "Mechanism of receptor-mediated modulation of the delayed outward potassium current in guinea-pig ventricular myocytes." @default.
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• W2034609232 doi "https://doi.org/10.1113/jphysiol.1990.sp017937" @default.
• W2034609232 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1190077" @default.
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