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- W2034609630 abstract "Epstein-Barr virus (EBV) related malignancies such as post-transplant lymphoproliferative disease (PTLD) are severe complications after allogeneic stem cell transplantation (SCT) and solid organ transplantation. In immune suppressed transplant recipients the activity of EBV-specific CTLs are often decreased or absent which leads to an increased risk of developing PTLD. If primary treatment modalities of PTLD fail, the most efficient way of treating the malignancy is adopting EBV-specific CTLs from the donor or, more recently, third-party donors. This is however both time-consuming and expensive and often it is too late to administer cells to the patient. We have for the first time, using a rapid isolation protocol of EBV-specific Tcells, treated and cured a patient suffering from PTLD with multiple associated tissue lesions, using her haplo-identical mother as a donor. This treatment approach paves way for a new possibility to within days treat patients with lifethreatening EBV-associated malignancies." @default.
- W2034609630 created "2016-06-24" @default.
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- W2034609630 date "2010-02-01" @default.
- W2034609630 modified "2023-09-26" @default.
- W2034609630 title "A Novel Haplo-Identical Adoptive CTL Therapy As Treatment For EBV-Associated Lymphoma After Stem Cell Transplantation" @default.
- W2034609630 doi "https://doi.org/10.1016/j.bbmt.2009.12.252" @default.
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