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• W2034609926 abstract "It has been reported that interleukin‐6 (IL‐6) is expressed in cells of acute inflammatory granulomas experimentally induced in mice by eggs of Schistosoma mansoni . Moreover, in vitro IL‐6 was shown to enhance the cytotoxic activity of human platelets against larvae of S. mansoni . To elucidate further a proposed biological significance of this cytokine during the course of schistosomiasis, we studied the kinetics of IL‐6 production and concomitantly performed a histopathological analysis of the livers in BALB/c mice subcutaneously infected with S. mansoni cercariae. Over a period of 24 weeks postinfection (p.i.) we monitored serum IL‐6 levels, IL‐6 production in vitro by pokeweed mitogen (PWM)‐stimulated spleen cells as well as IL‐6 mRNA expression in livers, spleens and kidneys. We found significantly elevated IL‐6 levels in PWM‐stimulated spleen cell‐conditioned media (SCM) at weeks 6 to 20 p.i., peaking at week 10 p.i. In contrast, serum IL‐6 concentrations started to rise not before week 8 but remained significantly elevated above normal control values until week 24 p.i. The time pattern of enhanced IL‐6 mRNA expression detected in spleens and livers, but not in kidneys, as well as the rises of IL‐6 in SCM and with a delay of 2 weeks in serum samples correlated with the onset of the egg‐induced inflammatory reactions as well as the incidence and the number of the granulomas observed histopathologically in the livers of infected mice. Our data emphasize both a local and a systemic role of IL‐6 in the host immune response following infection of mice with S. mansoni ." @default.
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• W2034609926 date "1996-10-01" @default.
• W2034609926 modified "2023-10-18" @default.
• W2034609926 title "<b>Kinetics of interleukin‐6 production after experimental infection of mice with <i>Schistosoma mansoni</i></b>" @default.
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• W2034609926 doi "https://doi.org/10.1046/j.1365-2567.1996.d01-737.x" @default.
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