Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034609970> ?p ?o ?g. }
- W2034609970 endingPage "537" @default.
- W2034609970 startingPage "529" @default.
- W2034609970 abstract "The antibody–drug conjugate field has made significant progress recently owing to careful optimization of several parameters, including mAb specificity, drug potency, linker technology, and the stoichiometry and placement of conjugated drugs. The underlying reason for this has been obtained in pre-clinical biodistribution and pharmacokinetics studies showing that targeted delivery leads to high intratumoral free drug concentrations, while non-target tissues are largely spared from chemotherapeutic exposure. Recent developments in the field have led to an increase in the number of ADCs being tested clinically, with 3 in late stage clinical trials: brentuximab vedotin (also referred to as SGN-35) for Hodgkin lymphoma; Trastuzumab-DM1 for breast cancer; and Inotuzumab ozogamicin for non-Hodgkin lymphoma. This review highlights the recent pre-clinical and clinical advances that have been made." @default.
- W2034609970 created "2016-06-24" @default.
- W2034609970 creator A5011719233 @default.
- W2034609970 creator A5072073795 @default.
- W2034609970 creator A5089318759 @default.
- W2034609970 date "2010-08-01" @default.
- W2034609970 modified "2023-10-11" @default.
- W2034609970 title "Antibody–drug conjugates: targeted drug delivery for cancer" @default.
- W2034609970 cites W1572828236 @default.
- W2034609970 cites W1967229902 @default.
- W2034609970 cites W1967808511 @default.
- W2034609970 cites W1971738718 @default.
- W2034609970 cites W1977241343 @default.
- W2034609970 cites W1984007340 @default.
- W2034609970 cites W1990918503 @default.
- W2034609970 cites W1994110235 @default.
- W2034609970 cites W1999146917 @default.
- W2034609970 cites W2000568282 @default.
- W2034609970 cites W2004275290 @default.
- W2034609970 cites W2004783782 @default.
- W2034609970 cites W2013933640 @default.
- W2034609970 cites W2023034663 @default.
- W2034609970 cites W2030177226 @default.
- W2034609970 cites W2049511540 @default.
- W2034609970 cites W2058332629 @default.
- W2034609970 cites W2074271171 @default.
- W2034609970 cites W2075002100 @default.
- W2034609970 cites W2077248326 @default.
- W2034609970 cites W2081249139 @default.
- W2034609970 cites W2083670340 @default.
- W2034609970 cites W2085489038 @default.
- W2034609970 cites W2088635881 @default.
- W2034609970 cites W2090057677 @default.
- W2034609970 cites W2099467058 @default.
- W2034609970 cites W2100314556 @default.
- W2034609970 cites W2101893838 @default.
- W2034609970 cites W2115292116 @default.
- W2034609970 cites W2116150122 @default.
- W2034609970 cites W2118167053 @default.
- W2034609970 cites W2124532648 @default.
- W2034609970 cites W2129901781 @default.
- W2034609970 cites W2131340972 @default.
- W2034609970 cites W2131478662 @default.
- W2034609970 cites W2132696220 @default.
- W2034609970 cites W2135967525 @default.
- W2034609970 cites W2136101268 @default.
- W2034609970 cites W2138352319 @default.
- W2034609970 cites W2138388661 @default.
- W2034609970 cites W2141105945 @default.
- W2034609970 cites W2150694237 @default.
- W2034609970 cites W2159744123 @default.
- W2034609970 cites W2166440745 @default.
- W2034609970 cites W2168148385 @default.
- W2034609970 cites W2171368669 @default.
- W2034609970 cites W2270326173 @default.
- W2034609970 cites W2553898478 @default.
- W2034609970 cites W2554233892 @default.
- W2034609970 cites W2560281006 @default.
- W2034609970 cites W2567825409 @default.
- W2034609970 cites W2576112374 @default.
- W2034609970 cites W2577583147 @default.
- W2034609970 doi "https://doi.org/10.1016/j.cbpa.2010.06.170" @default.
- W2034609970 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20643572" @default.
- W2034609970 hasPublicationYear "2010" @default.
- W2034609970 type Work @default.
- W2034609970 sameAs 2034609970 @default.
- W2034609970 citedByCount "557" @default.
- W2034609970 countsByYear W20346099702012 @default.
- W2034609970 countsByYear W20346099702013 @default.
- W2034609970 countsByYear W20346099702014 @default.
- W2034609970 countsByYear W20346099702015 @default.
- W2034609970 countsByYear W20346099702016 @default.
- W2034609970 countsByYear W20346099702017 @default.
- W2034609970 countsByYear W20346099702018 @default.
- W2034609970 countsByYear W20346099702019 @default.
- W2034609970 countsByYear W20346099702020 @default.
- W2034609970 countsByYear W20346099702021 @default.
- W2034609970 countsByYear W20346099702022 @default.
- W2034609970 countsByYear W20346099702023 @default.
- W2034609970 crossrefType "journal-article" @default.
- W2034609970 hasAuthorship W2034609970A5011719233 @default.
- W2034609970 hasAuthorship W2034609970A5072073795 @default.
- W2034609970 hasAuthorship W2034609970A5089318759 @default.
- W2034609970 hasConcept C112705442 @default.
- W2034609970 hasConcept C121608353 @default.
- W2034609970 hasConcept C126322002 @default.
- W2034609970 hasConcept C134306372 @default.
- W2034609970 hasConcept C143998085 @default.
- W2034609970 hasConcept C159654299 @default.
- W2034609970 hasConcept C178790620 @default.
- W2034609970 hasConcept C185592680 @default.
- W2034609970 hasConcept C197336794 @default.
- W2034609970 hasConcept C202751555 @default.
- W2034609970 hasConcept C203014093 @default.
- W2034609970 hasConcept C2777325958 @default.
- W2034609970 hasConcept C2777807558 @default.
- W2034609970 hasConcept C2778191690 @default.
- W2034609970 hasConcept C2778245361 @default.