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- W2034619410 abstract "The uptake of added adrenaline or noradrenaline from a suspension of partially depleted adrenergic nerve granules is not inhibited by reserpine about 10−5 M. On the other hand pretreatment of adrenergic nerve granules with reserpine in phosphate buffer for 1 hour prevents the amine uptake.Undepleted nerve granules which normally take up added adrenaline through exchange with noradrenaline fail to do so in the presence of reserpine owing to the concomitant block of noradrenaline release.L'incorporation d'adrénaline ou de noradrénalineàune suspension de granulations, présentant une déplétion partielle, des nerfs adrénergiques n'est pas inhibée par la réserpine 10−5M. Par contre, le traitement préalable avec la réserpine—incubation in vitro dans une solution tampon phosphatée—empêche la captation de ces amines.La réserpine inhibe l'incorporation d'adrenaline par les granulations non vidées par suite du blocage concommittant de la libération de noradrénaline.Die Aufnahme von zugesetztem Adrenalin oder Noradrenalin aus einer Suspension partiell entleerter adrenergischer Nervengranula wird durch Reserpin 10−5M in akuten Versuchen nicht gehemmt.Vorbehandlung von Nervengranula in vitro mit Reserpin 10−5M während 1 Stunde verhindert die Aminaufnahme bei nachfolgender Inkubation. In nicht entleerten Granula wird die Adrenalinaufnahme durch Reserpin gehemmt, wahrscheinlich wegen Mangel an Bindungsstätten, da die gleichzeitige Noradrenalinabgabe gehemmt ist." @default.
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- W2034619410 date "1962-02-01" @default.
- W2034619410 modified "2023-09-27" @default.
- W2034619410 title "The depleting effect of vincamin on the cerebral serotonin level" @default.
- W2034619410 doi "https://doi.org/10.1016/0006-2952(62)90105-3" @default.
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