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- W2034621130 endingPage "e25933" @default.
- W2034621130 startingPage "e25933" @default.
- W2034621130 abstract "Tissue barriers play an integral role in the biology and pathobiology of mammary ductal epithelium. In normal breast physiology, tight and adherens junctions undergo dynamic changes in permeability in response to hormonal and other stimuli, while several of their proteins are directly involved in mammary tumorigenesis. This review describes first the structure of mammary ductal epithelial barriers and their role in normal mammary development, examining the cyclical changes in response to puberty, pregnancy, lactation and involution. It then examines the role of adherens and tight junctions and the participation of their constituent proteins in mammary tumorigenic functions such as migration, invasion and metastasis. Finally, it discusses the potential of these adhesion proteins as both prognostic biomarkers and potential therapeutic targets in breast cancer." @default.
- W2034621130 created "2016-06-24" @default.
- W2034621130 creator A5041891022 @default.
- W2034621130 creator A5046559742 @default.
- W2034621130 creator A5082254713 @default.
- W2034621130 date "2013-08-09" @default.
- W2034621130 modified "2023-10-10" @default.
- W2034621130 title "Ductal barriers in mammary epithelium" @default.
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