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- W2034621801 abstract "In a previous in vitro study, we demonstrated the protective effects of a new drug, 2-cyclopropylimino-3-methyl-1,3-thiazoline hydrochloride (KHG26377), against glutamate-induced excitotoxicity in cultured glial cells. In this study, we explored the possible mechanisms underlying the neuroprotective and anti-inflammatory effects of this compound against glutamate-induced excitotoxicity in rat brain. Our results showed that pretreatment with KHG26377 significantly attenuated glutamate-induced elevation of lipid peroxidation, TNF-α, IFN-γ, nitric oxide, reactive oxygen species, NADPH oxidase, and Ca(2+) levels, as well as the expression of caspase-3, neuronal nitric oxide synthase, and pERK. Furthermore, KHG26377 pretreatment attenuated key antioxidant parameters such as levels of superoxide dismutase, catalase, glutathione, glutathione peroxidase, and glutathione reductase, and also mitigated suppression of mitochondrial transmembrane potential by glutamate toxicity. Thus, through its antioxidant and anti-inflammatory activities in rat brain, KHG26377 may help protect against glutamate-induced neuronal damage." @default.
- W2034621801 created "2016-06-24" @default.
- W2034621801 creator A5009749963 @default.
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- W2034621801 creator A5078229156 @default.
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- W2034621801 date "2013-09-01" @default.
- W2034621801 modified "2023-09-28" @default.
- W2034621801 title "Anti-oxidative and anti-inflammatory effects of 2-cyclopropylimino-3-methyl-1,3-thiazoline hydrochloride on glutamate-induced neurotoxicity in rat brain" @default.
- W2034621801 cites W1546592314 @default.
- W2034621801 cites W1565999785 @default.
- W2034621801 cites W1592721359 @default.
- W2034621801 cites W1606988289 @default.
- W2034621801 cites W1839369514 @default.
- W2034621801 cites W1909841186 @default.
- W2034621801 cites W1915946375 @default.
- W2034621801 cites W191793640 @default.
- W2034621801 cites W1965070196 @default.
- W2034621801 cites W1970195915 @default.
- W2034621801 cites W1971120748 @default.
- W2034621801 cites W1973063876 @default.
- W2034621801 cites W1973163231 @default.
- W2034621801 cites W1973768615 @default.
- W2034621801 cites W1975938392 @default.
- W2034621801 cites W1978166265 @default.
- W2034621801 cites W1978348298 @default.
- W2034621801 cites W1981183002 @default.
- W2034621801 cites W1985730861 @default.
- W2034621801 cites W1987362442 @default.
- W2034621801 cites W1987793916 @default.
- W2034621801 cites W2001637884 @default.
- W2034621801 cites W2002326485 @default.
- W2034621801 cites W2006823958 @default.
- W2034621801 cites W2007649442 @default.
- W2034621801 cites W2008139703 @default.
- W2034621801 cites W2009329139 @default.
- W2034621801 cites W2010057617 @default.
- W2034621801 cites W2011085845 @default.
- W2034621801 cites W2012992792 @default.
- W2034621801 cites W2013550947 @default.
- W2034621801 cites W2018334671 @default.
- W2034621801 cites W2020029292 @default.
- W2034621801 cites W2024387421 @default.
- W2034621801 cites W2028581240 @default.
- W2034621801 cites W2028806749 @default.
- W2034621801 cites W2029070849 @default.
- W2034621801 cites W2030354460 @default.
- W2034621801 cites W2031150484 @default.
- W2034621801 cites W2034862605 @default.
- W2034621801 cites W2036391216 @default.
- W2034621801 cites W2038419068 @default.
- W2034621801 cites W2048695976 @default.
- W2034621801 cites W2050709645 @default.
- W2034621801 cites W2052480734 @default.
- W2034621801 cites W2058638060 @default.
- W2034621801 cites W2058844322 @default.
- W2034621801 cites W2060180284 @default.
- W2034621801 cites W2061354386 @default.
- W2034621801 cites W2066036370 @default.
- W2034621801 cites W2066234282 @default.
- W2034621801 cites W2069273653 @default.
- W2034621801 cites W2077411940 @default.
- W2034621801 cites W2080560598 @default.
- W2034621801 cites W2082212013 @default.
- W2034621801 cites W2089755573 @default.
- W2034621801 cites W2097693778 @default.
- W2034621801 cites W2097739088 @default.
- W2034621801 cites W2099386577 @default.
- W2034621801 cites W2102182027 @default.
- W2034621801 cites W2106641866 @default.
- W2034621801 cites W2111102537 @default.
- W2034621801 cites W2135250775 @default.
- W2034621801 cites W2138006799 @default.
- W2034621801 cites W2140075873 @default.
- W2034621801 cites W2141260882 @default.
- W2034621801 cites W2141925460 @default.
- W2034621801 cites W2144437860 @default.
- W2034621801 cites W2144918294 @default.
- W2034621801 cites W2152394340 @default.
- W2034621801 cites W2159851687 @default.
- W2034621801 cites W2161456562 @default.
- W2034621801 cites W2169098158 @default.
- W2034621801 cites W2173757929 @default.
- W2034621801 cites W4242996363 @default.
- W2034621801 cites W4254946175 @default.
- W2034621801 cites W4293247451 @default.
- W2034621801 doi "https://doi.org/10.1016/j.neuro.2013.07.001" @default.
- W2034621801 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23867830" @default.
- W2034621801 hasPublicationYear "2013" @default.
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