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- W2034621906 abstract "Rat fetal brain and body tryptophan, and brain serotonin were measured at 15, 17, and 19 days postconception, and on the day of birth. Body tryptophan and brain serotonin increased with age during the last trimester of pregnancy; brain tryptophan increased only slightly during this time period. L-tryptophan injected into the mother or into neonates increased fetal and neonatal body and brain tryptophan, and brain serotonin at all ages studied. The dose- and time-relationships of 1-tryptophan-induced changes in brain tryptophan and serotonin were evaluated in 19 day old fetuses. The systemic administration of 1-tryptophan directly to the 19 day old fetus also increased brain serotonin. Thus, fetal brain serotonin neurons appear to have the capacity to synthesize the neurotransmitter from exogenously administered tryptophan, even though these neurons appear to be relatively immature." @default.
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- W2034621906 date "1975-09-01" @default.
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- W2034621906 title "L-tryptophan and rat fetal brain serotonin" @default.
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- W2034621906 doi "https://doi.org/10.1016/0024-3205(75)90538-x" @default.
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