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- W2034625995 abstract "Introduction: The Helicobacter pylori stool antigen (HpSA) enzyme immunoassay is a non-invasive test for the diagnosis and monitoring of H. pylori infection. However, there are few validation studies on the HpSA test after eradication in children. The aim of the study was to assess the diagnostic accuracy of HpSA test by ELISA method for the detection of H. pylori to confirm eradication in children. Methods: From January 2001 to October 2003, 164 tests were done in 146 children aged 1 to 17.5 years (mean 9.3–4.3 years). H. pylori infection was confirmed by gastroscopy-based studies (rapid urease test, histology and culture). All H. pylori infected children were treated with quadruple regimens (omeprazole, amoxicillin, metronidazole and bismuth subcitrate for 7 days). Stool specimens were collected from all patients for the HpSA tests by ELISA method (Primier platinum HpSA). The results of HpSA tests were interpreted as positive for OD <0.160, unresolved for 0.140 £ OD <0.160, and negative for OD <0.140 at 450nm on spectrophotometer. Results: 1) One hundred thirty-one HpSA tests were done before treatment. The results of HpSA tests showed three false positive results and one false negative result. The sensitivity, specificity, positive predictive value, and negative predictive value of HpSA enzyme immunoassay were 96.4%, 97.1%, 90% and 99% before treatment. 2) Thirty-three HpSA tests were done at least 4 weeks after eradication therapy. The results of HpSA tests showed two false positive results and one false negative result. The sensitivity, specificity, positive predictive value, and negative predictive value were 88.9%, 91.7%, 80% and 95.7% after treatment. Conclusion: Diagnostic accuracy of the HpSA enzyme immunoassay after eradication therapy was as high as that of the HpSA test before eradication therapy. The HpSA enzyme immunoassay was found to be a useful non-invasive method to confirm eradication in children." @default.
- W2034625995 created "2016-06-24" @default.
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- W2034625995 date "2004-06-01" @default.
- W2034625995 modified "2023-09-25" @default.
- W2034625995 title "P0071 PP ROLE OF THE HELICOBACTER PYLORI STOOL ANTIGEN (HPSA) TEST IN CONFIRMING ERADICATION AFTER QUADRUPLE THERAPY IN CHILDREN" @default.
- W2034625995 doi "https://doi.org/10.1097/00005176-200406001-00195" @default.
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