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• W2034626165 abstract "The conformation of synthetic or natural DNAs modified in vitro by covalent binding of N-AcO-A-Glu-P-3 was investigated by fluorescence and circular dichroism. In all cases, substitution occurs mainly on the C8 of guanine residues. In modified poly(dG-dC).poly(dG-dC) or poly(dA-dC).poly(dG-dT) in B conformation, A-Glu-P-3 residues interact strongly with the bases whereas in Z conformation these residues are largely exposed to the solvent and interact weakly with the bases. A-Glu-P-3 and N-acetyl-2-aminofluorene (AAF) residues are equally efficient to induce the B-Z transition of poly(dG-dC).poly(dG-dC) and of poly(dA-dC).poly(dG-dT). Modifications of poly(dG).poly(dC) and calf thymus DNA indicate strong interactions between A-Glu-P-3 and the bases." @default.
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• W2034626165 date "1984-01-01" @default.
• W2034626165 modified "2023-10-16" @default.
• W2034626165 title "Conformational changes induced in DNA by the<i>in vitro</i>reaction with the mutagenic amine: 3-N,N-acetoxyacetylainnio-4,6-dimethryldipyrido (l,2-a:3′,2′-d) imidazole" @default.
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• W2034626165 doi "https://doi.org/10.1093/nar/12.22.8553" @default.
• W2034626165 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/320398" @default.
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