Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034628047> ?p ?o ?g. }
- W2034628047 endingPage "3029" @default.
- W2034628047 startingPage "3022" @default.
- W2034628047 abstract "We identified the strategies to induce a CTL response to human papillomavirus (HPV) 16 E2 in HLA-A2 transgenic mice (AAD). A chimeric HPV16 virus-like particle (VLP) that includes full length HPV16 E7 and E2 (VLP-E7E2) was generated. The combination of E2 and E7 has the advantage that E2 is expressed in early dysplasia and neoplasia lesions, where E7 is expressed in more advance lesions. Since T cell response to E2 is less defined, we first evaluated the strategies to enhancing CD8+ T cell responses to HPV E7, using different combinations of immune-modulators with VLP-E7E2. Data showed that the CTL response to E7 could be significantly enhanced by coinjection of GM-CSF and antiCD40 antibodies with chimeric VLP-E7E2 without adjuvant. However, using the same combination, a low level of CD8+ T cell response to E2 was detected. To enhance the CD8+ T cell response to E2, we analyzed T cell epitopes from E2 sequence. A heterogonous prime-boost with chimeric VLP-E7E2 and E2 peptides was performed. The data showed that the priming with chimeric VLP-E7E2, followed by boosting with E2 peptides, gave a better CTL response than 2 immunizations with E2 peptides. The enhanced immunity is due to the increase of CD11c+ and CD11c+ CD40+ double positive dendritic cells in mice that received immune-modulators, GM-CSF and antiCD40. Furthermore, the level of anti-L1 antibodies remains similar in mice immunized with chimeric VLP with/without immune-modulators. Thus, the data suggested that the chimeric VLP-E7E2 has a therapeutic potential for the treatment of HPV-associated CINs and cancer without diminishing VLPs potential as a prophylactic vaccine by inducing anti-L1 antibodies against free virus. © 2006 Wiley-Liss, Inc." @default.
- W2034628047 created "2016-06-24" @default.
- W2034628047 creator A5013248904 @default.
- W2034628047 creator A5015135453 @default.
- W2034628047 creator A5026861780 @default.
- W2034628047 creator A5037193387 @default.
- W2034628047 creator A5040139068 @default.
- W2034628047 creator A5056265030 @default.
- W2034628047 creator A5075430537 @default.
- W2034628047 date "2006-01-01" @default.
- W2034628047 modified "2023-10-18" @default.
- W2034628047 title "Combined prophylactic and therapeutic cancer vaccine: Enhancing CTL responses to HPV16 E2 using a chimeric VLP in HLA-A2 mice" @default.
- W2034628047 cites W1494328783 @default.
- W2034628047 cites W1503003173 @default.
- W2034628047 cites W1518785179 @default.
- W2034628047 cites W1522781268 @default.
- W2034628047 cites W1579770523 @default.
- W2034628047 cites W1859510236 @default.
- W2034628047 cites W1889104568 @default.
- W2034628047 cites W1946675397 @default.
- W2034628047 cites W1967254492 @default.
- W2034628047 cites W1976933756 @default.
- W2034628047 cites W1979341960 @default.
- W2034628047 cites W1981383297 @default.
- W2034628047 cites W1981531030 @default.
- W2034628047 cites W2011418873 @default.
- W2034628047 cites W2014353718 @default.
- W2034628047 cites W2022234493 @default.
- W2034628047 cites W2028123682 @default.
- W2034628047 cites W2038615027 @default.
- W2034628047 cites W2038917355 @default.
- W2034628047 cites W2041433915 @default.
- W2034628047 cites W2052090282 @default.
- W2034628047 cites W2076140961 @default.
- W2034628047 cites W2077403314 @default.
- W2034628047 cites W2079484081 @default.
- W2034628047 cites W2079711957 @default.
- W2034628047 cites W2086315880 @default.
- W2034628047 cites W2086480947 @default.
- W2034628047 cites W2088288551 @default.
- W2034628047 cites W2088457548 @default.
- W2034628047 cites W2106595512 @default.
- W2034628047 cites W2106682089 @default.
- W2034628047 cites W2114357202 @default.
- W2034628047 cites W2117605168 @default.
- W2034628047 cites W2118149427 @default.
- W2034628047 cites W2119635842 @default.
- W2034628047 cites W2125556458 @default.
- W2034628047 cites W2128983157 @default.
- W2034628047 cites W2141696654 @default.
- W2034628047 cites W2142816353 @default.
- W2034628047 cites W2145426305 @default.
- W2034628047 cites W2156357292 @default.
- W2034628047 cites W2157989913 @default.
- W2034628047 cites W2160576748 @default.
- W2034628047 cites W2166010149 @default.
- W2034628047 cites W2400547513 @default.
- W2034628047 doi "https://doi.org/10.1002/ijc.21781" @default.
- W2034628047 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16425257" @default.
- W2034628047 hasPublicationYear "2006" @default.
- W2034628047 type Work @default.
- W2034628047 sameAs 2034628047 @default.
- W2034628047 citedByCount "27" @default.
- W2034628047 countsByYear W20346280472012 @default.
- W2034628047 countsByYear W20346280472013 @default.
- W2034628047 countsByYear W20346280472014 @default.
- W2034628047 countsByYear W20346280472015 @default.
- W2034628047 countsByYear W20346280472016 @default.
- W2034628047 countsByYear W20346280472018 @default.
- W2034628047 crossrefType "journal-article" @default.
- W2034628047 hasAuthorship W2034628047A5013248904 @default.
- W2034628047 hasAuthorship W2034628047A5015135453 @default.
- W2034628047 hasAuthorship W2034628047A5026861780 @default.
- W2034628047 hasAuthorship W2034628047A5037193387 @default.
- W2034628047 hasAuthorship W2034628047A5040139068 @default.
- W2034628047 hasAuthorship W2034628047A5056265030 @default.
- W2034628047 hasAuthorship W2034628047A5075430537 @default.
- W2034628047 hasConcept C100701293 @default.
- W2034628047 hasConcept C147969180 @default.
- W2034628047 hasConcept C154317977 @default.
- W2034628047 hasConcept C159047783 @default.
- W2034628047 hasConcept C159654299 @default.
- W2034628047 hasConcept C167672396 @default.
- W2034628047 hasConcept C195616568 @default.
- W2034628047 hasConcept C202751555 @default.
- W2034628047 hasConcept C203014093 @default.
- W2034628047 hasConcept C2776090121 @default.
- W2034628047 hasConcept C2777701055 @default.
- W2034628047 hasConcept C2777863537 @default.
- W2034628047 hasConcept C2778378633 @default.
- W2034628047 hasConcept C2779053233 @default.
- W2034628047 hasConcept C55493867 @default.
- W2034628047 hasConcept C59822182 @default.
- W2034628047 hasConcept C71924100 @default.
- W2034628047 hasConcept C81444415 @default.
- W2034628047 hasConcept C86803240 @default.
- W2034628047 hasConcept C8891405 @default.
- W2034628047 hasConceptScore W2034628047C100701293 @default.